血清ICAM-1、SCUBE-1、DCN水平与视网膜静脉阻塞患者血管内皮功能及预后相关性研究  

Correlation between serum ICAM-1,SCUBE-1 and DCN levels and vascular endothelial functionand prognosis in patients with retinal vein occlusion

作　　者：李玉红[1] 马凌葵 武桂云[1] LI Yuhong;MA Lingkui;WU Guiyun(Department of Ophthalmology,the First People’s Hospital of Tianmen in Hubei Province,Tianmen 431700,China)

机构地区：[1]湖北省天门市第一人民医院眼科,湖北天门431700

出　　处：《陕西医学杂志》2025年第2期258-262,共5页Shaanxi Medical Journal

基　　金：湖北省卫生健康科研立项课题(WJ2021F101)。

摘　　要：目的:探究血清细胞间黏附分子-1(ICAM-1)、信号肽-CUB-表皮生长因子结构域包含蛋白1(SCUBE-1)、核心蛋白多糖(DCN)水平与视网膜静脉阻塞(RVO)患者血管内皮功能及预后的相关性。方法:选取RVO患者58例(研究组)和同期体检健康者60例(对照组)。比较两组血清ICAM-1、SCUBE-1、DCN水平和血管内皮功能指标。采用Pearson法分析血清ICAM-1、SCUBE-1、DCN水平与患者血管内皮功能的相关性。根据RVO患者治疗后恢复情况将患者分为预后良好组(21例)和预后不良组(37例)。分析RVO患者预后的影响因素采用多因素Logistic回归。血清ICAM-1、SCUBE-1、DCN对RVO患者预后不良的预测价值通过绘制受试者工作特征(ROC)曲线进行分析。结果:研究组血清ICAM-1、SCUBE-1、DCN水平高于对照组(均P<0.05)。研究组反应性充血指数、一氧化氮水平低于对照组,血管内皮生长因子水平高于对照组(均P<0.05)。血清ICAM-1、SCUBE-1、DCN水平与反应性充血指数及一氧化氮呈负相关,与血管内皮生长因子呈正相关(均P<0.05)。预后良好组血清ICAM-1、SCUBE-1、DCN水平低于预后不良组(均P<0.05)。预后不良组患者合并高血压、视网膜静脉总干部位阻塞的比例高于预后良好组(均P<0.05)。血清ICAM-1、SCUBE-1、DCN、合并高血压、视网膜静脉阻塞部位为RVO患者预后的影响因素(均P<0.05)。血清ICAM-1、SCUBE-1、DCN以及三者联合预测RVO患者预后不良的曲线下面积(AUC)分别为0.804、0.793、0.802、0.933,且三者联合预测的AUC更高(均P<0.05)。结论:RVO患者血清ICAM-1、SCUBE-1、DCN水平升高,与血管内皮功能和预后有关,且三者联合对患者预后具有一定预测价值。Objective:To explore the correlation between serum levels of ICAM-1,SCUBE-1 and DCN and vascular endothelial function and prognosis in patients with retinal vein occlusion(RVO).Methods:A total of 58 RVO patients(study group)and 60 healthy individuals(control group)were selected.Serum levels of ICAM-1,SCUBE-1 and DCN,as well as vascular endothelial function indicators,were compared between the two groups.Pearson’s correlation analysis was used to assess the correlation between serum levels of ICAM-1,SCUBE-1 and DCN and patients’vascular endothelial function.RVO patients were divided into a good prognosis group(21 cases)and a poor prognosis group(37 cases)based on their recovery after treatment.Multifactorial logistic regression analysis was conducted to identify factors affecting the prognosis of RVO patients.ROC curves were plotted to analyze the predictive value of serum ICAM-1,SCUBE-1 and DCN for poor prognosis in RVO patients.Results:Serum levels of ICAM-1,SCUBE-1 and DCN in the study group were higher than those in the control group(all P<0.05).The study group had lower reactive hyperemia index and nitric oxide levels,and higher vascular endothelial growth factor levels compared to the control group(all P<0.05).Serum levels of ICAM-1,SCUBE-1 and DCN were negatively correlated with reactive hyperemia index and nitric oxide,and positively correlated with vascular endothelial growth factor(all P<0.05).The good prognosis group had lower serum levels of ICAM-1,SCUBE-1 and DCN than the poor prognosis group(all P<0.05).The poor prognosis group had a higher proportion of patients with hypertension and central retinal vein obstruction than the good prognosis group(all P<0.05).Serum ICAM-1,SCUBE-1,DCN,comorbidity of hypertension,and the site of retinal vein obstruction were identified as factors affecting the prognosis of RVO patients(all P<0.05).The AUC for predicting poor prognosis in RVO patients for serum ICAM-1,SCUBE-1,DCN and their combination were 0.804,0.793,0.802 and 0.933,respectively,with the combined pr

关 键 词：视网膜静脉阻塞 细胞间黏附分子-1 信号肽-CUB-表皮生长因子结构域包含蛋白1 核心蛋白多糖 血管内皮功能 预后 

分 类 号：R774.1[医药卫生—眼科]