HER2、SALL4、GATA3蛋白在乳腺癌组织中的表达及其与患者临床病理特征和预后相关性研究  

Expression of HER2,SALL4 and GATA3 proteins in breast cancer tissues and their correlation with clinical pathological characteristics and prognosis in patients with breast cancer

作　　者：陈达 徐磊[1] 夏秋月 时登娟 CHEN Da;XU Lei;XIA Qiuyue;SHI Dengjuan(Department of Pathology,Linyi People’s Hospital,Linyi 276100,China)

机构地区：[1]临沂市人民医院病理科,山东临沂276100

出　　处：《陕西医学杂志》2025年第2期272-276,共5页Shaanxi Medical Journal

基　　金：山东省卫生健康委员会科研项目(BK2021F0127)。

摘　　要：目的:探讨乳腺癌组织中人类表皮生长因子受体2(HER2)、婆罗双树样基因4(SALL4)、GATA结合蛋白3(GATA3)蛋白表达及其与患者临床病理特征和预后的相关性。方法:选取乳腺癌患者138例,收集患者癌组织和癌旁正常组织标本。癌组织和癌旁组织中HER2、SALL4、GATA3蛋白表达采用免疫组织化学染色法检测。对患者进行5年随访,行Cox回归分析乳腺癌患者预后的影响因素。结果:与癌旁组织比较,乳腺癌组织中HER2、SALL4蛋白阳性表达率升高,GATA3蛋白阳性表达率降低(均P<0.05)。乳腺癌组织HER2、SALL4、GATA3蛋白阳性表达与患者TNM分期和淋巴结转移有关(均P<0.05)。TNM分期Ⅲ-Ⅳ期、有淋巴结转移、HER2蛋白阳性表达、SALL4蛋白阳性表达、GATA3蛋白阴性表达为乳腺癌患者5年内预后不良的独立影响因素(均P<0.05)。HER2、SALL4蛋白阳性表达患者5年生存率低于阴性患者,GATA3阴性患者5年生存率低于阳性患者(均P<0.05)。结论:乳腺癌组织HER2、SALL4蛋白高表达、GATA3蛋白低表达,且三者与乳腺癌患者淋巴结转移、TNM分期和预后有关。Objective:To investigate the expression of human epidermal growth factor receptor 2(HER2),spalt-like transcription factor 4(SALL4)and GATA-binding protein 3(GATA3)in breast cancer tissues and their correlation with clinical pathological characteristics and prognosis in patients with breast cancer.Methods:A total of 138 patients with breast cancer were selected,and cancerous and adjacent normal tissue specimens were collected from these patients.Immunohistochemical staining was used to detect the expression of HER2,SALL4,and GATA3 proteins in cancerous and adjacent tissues.A 5-year follow-up was conducted for the patients,and Cox regression analysis was performed to identify the influencing factors on the prognosis of patients with breast cancer.Results:Compared with adjacent tissues,the positive expression rates of HER2 and SALL4 proteins were increased,while the positive expression rate of GATA3 protein was decreased in breast cancer tissues(all P<0.05).The positive expression of HER2,SALL4 and GATA3 proteins in breast cancer tissues was related to the patient’s TNM staging and lymph node metastasis(all P<0.05).TNM stageⅢ-Ⅳ,lymph node metastasis,positive expression of HER2 and SALL4 protein,and negative expression of GATA3 protein were identified as independent factors affecting the poor prognosis of patients with breast cancer within 5 years(all P<0.05).Patients with positive expression of HER2 and SALL4 proteins had lower 5-year survival rates than those with negative expression,and patients with negative GATA3 had lower 5-year survival rates than those with positive expression(all P<0.05).Conclusion:High expression of HER2 and SALL4 proteins,and low expression of GATA3 protein in breast cancer tissues are associated with lymph node metastasis,TNM staging and prognosis in patients with breast cancer.

关 键 词：乳腺癌 人类表皮生长因子受体2 婆罗双树样基因4 GATA结合蛋白3 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]