表观遗传学m6A修饰与肿瘤糖代谢重编程  

Epigenetic m6A modification and reprogramming of tumor glucose metabolism

作　　者：于菁 林宇[2] Yu Jing;Lin Yu(The Affiliated Hospital of Inner Mongolia Medical University,1Department of Radiation Hematology,Hohhot 010050;The Affiliated Hospital of Inner Mongolia Medical University,Department of Radiation Therapy,Hohhot 010050)

机构地区：[1]内蒙古医科大学附属医院血液科,呼和浩特010050 [2]内蒙古医科大学附属医院放疗科,呼和浩特010050

出　　处：《中国组织化学与细胞化学杂志》2024年第4期391-396,共6页Chinese Journal of Histochemistry and Cytochemistry

基　　金：内蒙古医科大学科技百万工程联合项目(YKD2020KJBW(LH)006);内蒙古医科大学青年培育项目(YKD2021QN042);2023年重点学科临床医学-肿瘤多学科综合体系建设(DC2300000607);内蒙古医科大学附属医院博士科研启动金(2022NYFYBS006);内蒙古医科大学面上项目(YKD2021MS015);内蒙古自治区自然科学项目(2023LHMS08060);内蒙古自治区科技计划项目(2021GG0204);“草原英才”滚动支持个人。

摘　　要：糖酵解重编程是癌症的关键特征之一,且在癌症的进展过程中发挥着至关重要的作用。在癌细胞中,糖代谢的改变不仅促进肿瘤蛋白信号通路、改变表观遗传及转录修饰、促进肿瘤细胞增殖及抗凋亡还深刻影响癌症的免疫逃逸、预后评估和治疗效果。RNA的m6A修饰广泛存在于真核细胞中,且这一修饰是动态且可逆的。N6-甲基腺嘌呤(N6-methyladenosine,m6A)修饰在调控肿瘤干细胞的更新与分化、肿瘤治疗抵抗、肿瘤微环境、肿瘤免疫逃逸以及肿瘤代谢等方面起着重要作用。近年来,越来越多的研究证据表明,m6A修饰通过多种途径影响肿瘤的糖酵解过程,从而调控肿瘤的生物学行为。在本文中,我们将探讨糖酵解在肿瘤发生与发展的作用,并深入分析m6A修饰通过调节糖酵解对不同肿瘤类型的深远影响,旨在为针对m6A修饰的糖酵解调控提供肿瘤预防与治疗的理论依据。Glycolytic reprogramming is one of the key hallmarks of cancer and plays a crucial role in the progression of cancer.In cancer cells,alterations in glucose metabolism not only promote tumor protein signaling pathways,alter epigenetic and transcriptional modifications,and enhance tumor cell proliferation and anti-apoptosis,but also significantly affect immune evasion,prognosis assessment,and treatment outcomes in cancer.N6-methyladenosine(m6A)RNA modification is widely present in eukaryotic cells and is a dynamic and reversible modification.m6A modification plays an important role in regulating tumor stem cell renewal and differentiation,tumor treatment resistance,tumor microenvironment,immune evasion,and tumor metabolism.In recent years,increasing evidence suggests that m6A modification influences the glycolytic process in tumors through various pathways,thereby regulating tumor biology.In this article,we will explore the role of glycolysis in tumor initiation and progression,and provide an in-depth analysis of how m6A modification regulates glycolysis in different tumor types,offering important theoretical value for targeting m6A-modulated glycolysis in cancer prevention and treatment.

关 键 词：N6-甲基腺嘌呤 肿瘤 糖酵解 乳酸 糖代谢重编程 

分 类 号：R730.2[医药卫生—肿瘤]