彩色多普勒超声联合血清甲状腺球蛋白抗体鉴别诊断甲状腺良恶性微小结节的价值  

Value of color Doppler ultrasound combined with serum thyroglobulin antibody in differential diagnosis of benign and malignant thyroid micronodules

作　　者：王芳 邹莉莉 陈洪标 WANG Fang;ZOU Lili;CHEN Hongbiao(Department of Ultrasonography,Fuzhou Directly Affiliated Outpatient Department,Fuzhou,Jiangxi,344000,China)

机构地区：[1]抚州市直属门诊部超声科,江西抚州344000

出　　处：《当代医学》2024年第23期124-127,共4页Contemporary Medicine

基　　金：抚州市指导性科技计划项目(抚科社字〔2022〕9号,第55项)。

摘　　要：目的探讨彩色多普勒超声联合血清甲状腺球蛋白抗体(thyroglobulin antibody,TgAb)鉴别诊断甲状腺良恶性微小结节的价值。方法选取2022年9月至2024年1月抚州市直属门诊部收治的70例甲状腺良恶性微小结节患者作为研究对象,所有患者均接受血清TgAb检测和彩色多普勒超声检查,并均经手术病理学检查证实。以病理学检查结果为金标准,分析血清TgAb、彩色多普勒超声及联合检查对甲状腺恶性微小结节的诊断价值。结果70例甲状腺微小结节患者中,病理学检查检出良性40例,恶性30例;血清TgAb检测检出良性33例,恶性37例;彩色多普勒超声检出良性33例,恶性37例;联合检查检出良性39例,恶性31例。3种检查方法特异度、准确度、阳性预测值、阴性预测值比较差异有统计学意义(P<0.05),其中联合检查特异度、准确度、阳性预测值均高于血清TgAb、彩色多普勒超声单独检查,差异有统计学意义(P<0.017),3种检查方法阴性预测值两两比较及血清TgAb与彩色多普勒超声单独检查特异度、准确度、阳性预测值比较差异均无统计学意义。结论彩色多普勒超声联合血清TgAb鉴别诊断甲状腺良恶性微小结节的价值较高,具有较高的特异度、准确度,值得临床推广应用。Objective To explore the value of color Doppler ultrasound combined with serum thyroglobulin antibody(TgAb)in the differential diagnosis of benign and malignant thyroid micronodules.Methods A total of 70 patients with benign and malignant thyroid micronodules admitted to the Fuzhou Directly Affiliated Outpatient Department from September 2022 to January 2024 were selected as the study subjects,all patients underwent serum TgAb detection and color Doppler ultrasound examination,and all were confirmed by pathological examination.The diagnostic value of serum TgAb,color Doppler ultrasound and combined examination for malignant thyroid small nodules was analyzed with pathological examination results as the gold standard.Results Among the 70 patients with thyroid micronodules,40 were benign and 30 were malignant by pathological examination;33 cases of benign and 37 cases of malignant were detected by serum TgAb;33 cases of benign and 37 cases of malignant were detected by color Doppler ultrasound;39 cases of benign and 31 cases of malignant were detected by combined examination.There were statistically significant differences in the specificity,accuracy and positive predictive value and negative predictive value among the three methods(P<0.05),and the specificity,accuracy and positive predictive value of the combined examination were higher than those of serum TgAb and color Doppler ultrasonography alone(P<0.017),but there were no statistically significant differences in the negative predictive value of the pairwise comparison among the three examination methods,and the specificity,accuracy and positive predictive value between serum TgAb and color Doppler ultrasonography.Conclusion Color Doppler ultrasound combined with serum TgAb has a high value in the differential diagnosis of benign and malignant thyroid micronodules,with high specificity and accuracy,and is worthy of clinical promotion and application.

关 键 词：彩色多普勒超声 血清甲状腺球蛋白抗体 鉴别诊断 甲状腺良恶性结节 

分 类 号：R73[医药卫生—肿瘤]