孕激素受体、雌激素受体和增殖细胞核抗原在子宫内膜癌中的表达及与临床病理特征的相关性  

Expression of progesterone receptor,estrogen receptor,and proliferating cell nuclear antigen in endometrial cancer and their correlation with clinical pathological features

作　　者：徐丽艳[1] 苏碧蓉 XU Liyan;SU Birong(Department of Pathology,Xiamen Third Hospital,Fujian Province,Xiamen 361100,China)

机构地区：[1]福建省厦门市第三医院病理科,福建厦门361100

出　　处：《中国当代医药》2024年第35期34-37,共4页China Modern Medicine

摘　　要：目的探讨孕激素受体(PR)、雌激素受体(ER)、增殖细胞核抗原(Ki-67)在子宫内膜癌(EC)中的表达情况。方法选取2020年2月至2023年10月于厦门市第三医院行手术治疗的84例EC患者且术中采集癌组织标本作为观察组,因其他因素获取的84份子宫标本作为对照组。用免疫组织化学法测定ER、PR、Ki-67表达情况。比较不同标本内ER、PR、Ki-67阳性表达率,分析ER、PR、Ki-67表达与EC患者临床病理特征的相关性。结果观察组ER阳性表达率为53.57%(45/84)、PR阳性表达率为44.05%(37/84),低于对照组[85.71%(72/84)、54.52%(71/84)],Ki-67阳性表达率为59.52%(50/84),高于对照组[19.05%(16/84)],差异有统计学意义(P<0.05)。不同分化程度、病理分期、淋巴结转移、肌层浸润深度、脉管浸润者ER、PR、Ki-67阳性表达率比较,差异有统计学意义(P<0.05)。Pearson分析显示,ER、PR阳性表达与分化程度、淋巴结转移、病理分期、肌层浸润深度、脉管浸润均呈负相关,Ki-67与上述情况均呈正相关(P<0.05)。结论EC组织内ER、PR呈低表达,Ki-67呈高表达,三者异常表达与患者临床病理特征关系密切,可作为诊断和监测患者病情严重程度指标。Objective To investigate the expression of progesterone receptor(PR),estrogen receptor(ER),and proliferating cell nuclear antigen(Ki-67)in endometrial cancer(EC).Methods A total of 84 EC patients who underwent surgical treatment at Xiamen Third Hospital from February 2020 to October 2023 and had cancer tissue specimens collected during surgery were selected as the observation group,and 84 uterine specimens obtained due to other factors were selected as the control group.The expression of ER,PR and Ki-67 was measured using immunohistochemistry.The positive expression rates of ER,PR and Ki-67 in different specimens,and analyze the correlation between ER,PR,Ki-67 expression and the clinical pathological characteristics of EC patients were compared.Results The positive expression rates of ER and PR in the observation group were 53.57%(45/84)and 44.05%(37/84),respectively,which were lower than those in the control group(85.71%[72/84]and 54.52%[71/84]),respectively.The positive expression rate of Ki-67 was 59.52%(50/84),which was higher than that in the control group(19.05%[16/84]),and the difference was statistically significant(P<0.05).There were statistically significant differences in the positive expression rates of ER,PR and Ki-67 among patients with different differentiation degrees,pathological stages,lymph node metastasis,depth of muscle infiltration and vascular infiltration(P<0.05).Pearson analysis showed that ER and PR positive expression were negatively correlated with differentiation degrees,lymph node metastasis,pathological stages,depth of muscle infiltration and vascular infiltration,while Ki-67 was positively correlated with the above conditions(P<0.05).Conclusion ER and PR show low expression in EC tissues,while Ki-67 shows high expression.The abnormal expression of these three factors is closely related to the clinical and pathological characteristics of patients,and can be used as diagnostic and monitoring indicators for the severity of the patient's condition.

关 键 词：子宫内膜癌 孕激素受体 临床病理特征 雌激素受体 增殖细胞核抗原 

分 类 号：R737.3[医药卫生—肿瘤]