铁皮石斛咀嚼片的配方优化及品质分析  

Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets

作　　者：张雯钰 付贤树 白雪 吴诗雯 李佳斌 俞晓平 张明洲 叶子弘 ZHANG Wenyu;FU Xianshu;BAI Xue;WU Shiwen;LI Jiabin;YU Xiaoping;ZHANG Mingzhou;YE Zihong(College of Life Sciences,China Jiliang University,Key Laboratory of Biometrics,Inspection and Quarantine of Zhejiang Province,Hangzhou 310018,China;Food Company Limited of Hangzhou Baichen,Hangzhou 311251,China)

机构地区：[1]中国计量大学生命科学学院,浙江省生物计量及检验检疫重点实验室,浙江杭州310018 [2]杭州百晨食品有限公司,浙江杭州311251

出　　处：《食品工业科技》2025年第4期155-166,共12页Science and Technology of Food Industry

基　　金：杭州市科技特派员专项项目(20231122t12)。

摘　　要：为探究能否利用铁皮石斛、黄精、红枣作为主料,开发出一种便于携带与食用的功能性休闲食品。本文采用最优混料实验设计(DOE)方案,以混合主料中测得的多糖、黄酮、多酚质量分数为指标确定铁皮石斛、黄精、红枣的最优配比。后采用单因素实验研究辅料对咀嚼片外观、口感、硬度以及重量差异的影响并结合响应面优化试验与多指标权重法,以综合评分为指标选取主、辅料最优配方。结果表明,铁皮石斛咀嚼片主料最优复配比例(质量分数)为铁皮石斛:黄精:红枣=35%:10%:5%,对应的多糖、黄酮和多酚总质量分数分别为159.64±0.14、79.44±0.35和78.10±0.28 mg/g;辅料部分赤藓糖醇、甘露醇和乳清蛋白质量分数比分别为13%、13%和6%。最优配方下铁皮石斛咀嚼片的产品外观评分、口感评分、硬度与重量差异分别为7.80±0.63分、7.80±0.42分、23.72±0.15 N,2.57%±0.13%,综合评分为21.87±0.83分。铁皮石斛咀嚼片物理性质评价及溶出度检测结果显示,其含水量、粘附性、弹性、咀嚼性分别为2.23%±0.92%、12.75±0.54 mJ、7.08±0.58 mm、0.41±0.67 mJ,且在60 min时累计溶出度达79.80%±0.75%。由铁皮石斛、黄精、红枣为原料制得的咀嚼片有效成分含量高,感官评价好,易于溶出。To explore whether Dendrobium officinale,Polygonatum sibiricum,and Ziziphus jujuba can be used as active pharmaceutical ingredient(APIs),a functional snack that is easy to carry and eat was developed.In this study,the design of experiment(DOE)scheme was used to determine the optimal ratio of D.officinale,P.sibiricum,and Z.jujuba based on the measured mass fractions of polysaccharides,flavonoids,and polyphenols in the drug.A single-factor experiment was used to study the effects of excipients on the appearance,taste,hardness,and weight difference of chewable tablets,and the optimal formula was selected by combining the response surface optimization and multi-index weight methods.Results showed that the optimal compound ratio of the main ingredients of D.officinale chewable tablets(mass fraction)was D.officinale:P.sibiricum:Z.jujuba=35%:10%:5%,and the corresponding total mass fractions of polysaccharides,flavonoids,and polyphenols were 159.64±0.14,79.44±0.35,and 78.10±0.28 mg/g,respectively.The mass fraction ratios of erythritol,mannitol,and whey protein in the excipient fractions were 13%,13%,and 6%,respectively.The differences in appearance,taste,hardness,and weight of D.officinale chewable tablets under the optimal formula were 7.80±0.63 points,7.80±0.42 points,23.72±0.15 N,and 2.57%±0.13%,respectively.The comprehensive score was 21.87±0.83 points.Results of physical property evaluation and the dissolution test of D.officinale chewable tablets showed that the water content,adhesion,elasticity,and chewiness were 2.23%±0.92%,12.75±0.54 mJ,7.08±0.58 mm,and 0.41±0.67 mJ,respectively,and the cumulative dissolution reached 79.80%±0.75%at 60 min.Chewable tablets made from D.officinale,P.sibiricum,and Z.jujuba have a high active ingredient content,good sensory evaluation,and easy dissolution.

关 键 词：铁皮石斛 咀嚼片 实验设计 响应面优化 溶出度 

分 类 号：R943.1[医药卫生—药剂学]