唑吡坦联合曲唑酮片对帕金森病睡眠障碍老年患者睡眠结构及认知功能的影响  

Effects of Zolpidem Combined with Trazodone Tablets on Sleep Structure and Cognitive Function in Elderly Patients with Parkinson's Disease

作　　者：蒋旭 陈雅宁 潘杨[1] JIANG Xu;CHEN Yaning;PAN Yang(Department of Geriatrics,Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学附属脑科医院老年医学科,南京210029

出　　处：《转化医学杂志》2024年第8期1289-1293,共5页Translational Medicine Journal

基　　金：2020年江苏省干部保健科研项目(BJ20005);2023年江苏省卫健委老龄健康专项资金(苏卫老健[2023]5号)。

摘　　要：目的 探讨唑吡坦联合曲唑酮片对帕金森病睡眠障碍(PDSD)老年患者睡眠结构及认知功能的改善效果。方法 选取2019年8月至2024年7月诊治的100例老年PDSD患者,按照随机数字表法将其分为对照组和观察组,每组50例。对照组接受帕金森病常规治疗加唑吡坦,观察组在此基础上联合曲唑酮片。评估2组睡眠结构、简易精神状态检查(MMSE)、匹兹堡睡眠质量(PSQI)及蒙特利尔认知评估(MoCA)量表评分。结果 治疗后,观察组N1期、N2期占比,觉醒时间、觉醒次数、睡眠潜伏期较对照组均显著降低,N3期、REM期较对照组均显著升高(P<0.05)。治疗后,2组患者PSQI量表得分较治疗前均显著降低,且观察组低于对照组(P<0.01)。观察组总有效率为[92.00%(46/50)]高于对照组[74.00%(37/50)],差异有统计学意义(P<0.05)。治疗后,2组患者MMSE、MoCA得分相较于治疗前均显著升高,且观察组高于对照组(P<0.05,P<0.01)。结论 唑吡坦联合曲唑酮片能够显著改善PDSD老年患者的睡眠结构及认知功能,增强临床疗效。Objective To investigate the effects of Zolpidem combined with Trazodone tablets on sleep structure and cognitive function in elderly patients with Parkinson's disease sleep disorder(PDSD).Methods 100 elderly PDSD patients diagnosed and treated from August 2019 to July 2024 were divided into control group and observation group according to ran⁃dom number table method,with 50 cases in each group.The control group received conventional treatment for Parkinson's dis⁃ease plus Zolpidem,and the observation group was combined with Trazodone tablets on this basis.The sleep structure,Simple mental state Examination(MMSE),Pittsburgh Sleep Quality(PSQI)and Montreal Cognitive Assessment(MoCA)scales were evaluated.Results After treatment,the proportion of N1 stage,N2 stage,wake time,wake times and sleep latency in observation group were significantly decreased compared with control group,while N3 stage and REM stage were significantly increased compared with control group(P<0.05).After treatment,PSQI scores in 2 groups were significantly lower than be⁃fore treatment,and the observation group was lower than the control group(P<0.01).The total effective rate of the observa⁃tion group was[92.00%(46/50)]higher than that of the control group[74.00%(37/50)],and the difference was statisti⁃cally significant(P<0.05).After treatment,MMSE and MoCA scores in 2 groups were significantly higher than before treat⁃ment,and the observation group was higher than the control group(P<0.05,P<0.01).Conclusion Zolpidem combined with Trazodone can significantly improve sleep structure and cognitive function in elderly patients with PDSD,and enhance clinical efficacy.

关 键 词：帕金森病 睡眠障碍 唑吡坦 曲唑酮片 简易精神状态检查 匹兹堡睡眠质量 蒙特利尔认知评估 

分 类 号：R742.5[医药卫生—神经病学与精神病学]