基因指导降压药物选择对高血压患者疗效以及PI3K/AKT信号通路的影响  

Effect of gene-guided antihypertensive drug selection on curative effect and PI3K/AKT signaling pathway in patients with hypertension

作　　者：刘继成 LIU Ji-cheng(Department of Cardiovascular Medicine,Zhumadian Central Hospital,Zhumadian,Henan 463000,China)

机构地区：[1]驻马店市中心医院心血管内一科,河南驻马店463000

出　　处：《医药论坛杂志》2024年第23期2498-2502,共5页Journal of Medical Forum

摘　　要：目的基于磷脂酰肌醇3-激酶/丝氨酸苏氨酸激酶(phosphatidylinosutol-3-kinase/Serine threoninekinase,PI3K/AKT)信号通路探讨抗高血压药物基因检测在高血压中的应用效果。方法本研究选取2022年1月—2024年5月期间于驻马店市中心医院就诊的高血压患者160例作为观察对象,根据其是否接受高血压基因检测分为基因组(n=80)和对照组(n=80),并根据检测结果给予不同的抗高血压药物治疗,给予对照组常规降压治疗。观察两组不良反应发生情况和治疗效果,并对其治疗前后的血压控制水平、生活质量、内皮功能指标及PI3K/AKT信号通路相关指标进行比较。结果基因组治疗效果更佳,发生不良反应风险更低,差异有统计学意义(均P<0.05),且经治疗后的舒张压、收缩压、血清(endothelin-1,ET–1)及PI3K/AKT信号通路相关指标(PI3K、AKT、B细胞淋巴瘤基因-2及Bcl-2相关X蛋白)均较对照组偏低,差异有统计学意义(均P<0.05),其血清NO、FMD水平和生活质量评分较高,差异有统计学意义(均P<0.05)。结论抗高血压药物基因检测可指导临床制定更为合理的降血压方案,从而起到更好的降压效果,更明显的下调TLR4/NF-kB炎性信号通路水平。Objective To explore the application effect of gene detection of antihypertensive drugs in hypertension based on PI3K/AKT signaling pathway.Methods In this study,160 patients with hypertension who visited our hospital from January,2022 to May,2024 were selected as the observation objects.They were divided into genome(n=80)and control group(n=80)according to whether they accepted the hypertension gene test,and were given different antihypertensive drugs according to the test results,and the control group was given routine antihypertensive treatment.The adverse reactions and therapeutic effects of the two groups were observed,and the blood pressure control level,quality of life,endothelial function and PI3K/AKT signaling pathway were compared before and after treatment.Results The effect of genome therapy was better,and the risk of adverse reactions was lower(all P<0.05).After treatment,the diastolic blood pressure,systolic blood pressure,serum ET-1 and PI3K/AKT signaling pathway related indicators(PI3K,AKT,B-cell lymphoma gene-2 and Bcl-2 related X protein)were lower than those of the control group(all P<0.05),and the serum NO,FMD level,and life quality score were higher than those of the control group(all P<0.05).Conclusion Gene detection of antihypertensive drugs can guide the clinical formulation of a more reasonable antihypertensive plan,thus achieving a better antihypertensive effect and significantly lowering the level of TLR4/NF-kB inflammatory signaling pathway.

关 键 词：TLR4/NF-kB信号通路 抗高血压药物 基因检测 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]