脂肪基质血管组分的临床研究进展  

Clinical research progress of fat stromal vascular fraction

作　　者：王怡 李一佳 李效敬 张美荣 汤苏阳 

机构地区：[1]迈迪速能医学技术(天津)有限公司,天津300399 [2]中国医药生物技术协会皮肤软组织修复与重建技术分会,北京100022 [3]华夏(青岛)生物科技有限公司,青岛266000

出　　处：《中国医药生物技术》2025年第1期95-100,共6页Chinese Medicinal Biotechnology

基　　金：青岛市未来产业培育专项(24-1-4-xxgg-10-nsh)。

摘　　要：从脂肪移植、骨骼疾病、软骨疾病到皮肤修复,脂肪基质血管组分(SVF)的临床研究涉及多个领域,并且已经取得了有益的效果。由于脂肪SVF是一种多细胞的异质细胞群,因此其在再生医学领域可以发挥重要作用,具有组织修复、免疫调节、促进血管生成等作用,相较传统的干细胞治疗,可以更加全面系统地对受损组织进行修复。在软骨修复、辅助移植等方面已取得了良好的临床效果,脂肪SVF治疗膝骨关节炎、股骨头坏死等已成为临床治疗方案之一。并且相较与其他细胞治疗方式,体外操作遵循最小操作原则,安全性相较更好。而目前临床治疗主要应用的SVF类型还是以酶解法获得的SVF为主,此方式获取的SVF为纯细胞组分,可以更好地发挥各种细胞的作用,并且有利进行质量监督与控制。本文综述了近年来脂肪SVF在临床治疗的案例,讨论脂肪SVF的给药途径、给药剂量、治疗效果等问题。但由于案例数相对较少,安全性观察期较短,并且对于其治疗机制还未研究透彻,这些制约SVF全面进入临床治疗的问题亟待解决。From fat transplantation,bone disease,cartilage disease to skin repair,the clinical trails of stromal vascular fraction(SVF)involve many fields and have achieved beneficial results.Since fat SVF is a multi-cell heterogeneous group of cells,it can play a vital role in the field of regenerative medicine with effects on tissue repair,immune regulation,and angiogenesis promotion.Compared to traditional stem cell therapy,it can comprehensively and systematically repair damaged tissues.Fat SVF has shown beneficial results in cartilage repair and assisted transplantation,and has become one choice in the treatment of osteoarthritis and osteonecrosis of the femoral head.Compared with other cell therapies,fat SVF follows the principle of minimum operation in vitro and is safer.Currently,the main type of SVF used in clinical treatment is obtained by enzymatic digestion.The SVF obtained by this method consists of pure cell components,enhancing the performance of cells in their respective functions and conducive to quality control and supervision.This article reviews recent clinical cases involving fat SVF and discusses the route of administration,dosage,therapeutic effects,and etc.However,the problems such as relatively few cases available,the short observation period for safety assessment,and the lack of thorough research on its treatment mechanisms,need to be addressed before introducing SVF into clinical treatment.

关 键 词：脂肪移植 基质血管组分 酶解法 脂肪组织 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]