Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxelmirrored homotopic connectivity:a resting state fMRI study  

作　　者：Xue-Lin Wang Yu Chen Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang Yan-Mei Zeng Xiao-Yu Wang Qian-Min Ge Xu Chen Yi Shao 

机构地区：[1]Department of Ophthalmology,the First Affiliated Hospital of Jiangxi Medical College,Shangrao Center Hospital,Eye Hospital of Shangrao City,Shangrao 334000,Jiangxi Province,China [2]Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,Liaoning Province,China [3]Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China [4]School of Optometry and Vision Science,Cardiff University,Cardiff,CF244HQ,Wales,UK [5]Ophthalmology Centre of Maastricht University,Maastricht 6200MS,Limburg Provincie,the Netherlands [6]Department of Ophthalmology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Eye Diseases,Shanghai 200080,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第2期297-307,共11页国际眼科杂志(英文版)

基　　金：Supported by National Natural Science Foundation of China(No.82160195,No.82460203).

摘　　要：AIM:To analyze whether alterations of voxel mirror homology connectivity(VMHC)values,as determined by resting-state functional magnetic resonance imaging(rsfMRI),occur in cerebral regions of patients with hypertensive retinopathy(HR)and to determine the relationship between VMHC values and clinical characteristics in patients with HR.METHODS:Twenty-one patients with HR and 21 agematched healthy controls(HCs)were assessed by rsfMRI scanning.The functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC,with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic(ROC)curve analysis.Differences in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample t-tests.The relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation analysis.RESULTS:Mean VMHC values of the bilateral cuneus gyrus(BA19),bilateral middle orbitofrontal gyrus(BA47),bilateral middle temporal gyrus(BA39)and bilateral superior medial frontal gyrus(BA9)were lower in the HR than in the HC group.CONCLUSION:VMHC values can predict the development of early HR,prevent the transformation of hypertensive microangiopathy,and provide useful information explaining the changes in neural mechanism associated with HR.

关 键 词：hypertensive retinopathy voxel-mirrored homotopic connectivity NEUROIMAGING functional MRI resting state 

分 类 号：R73[医药卫生—肿瘤]