Visual electrophysiological assessment of children with poor response to treatment for functional amblyopia  

作　　者：Dong-Qing Yuan Wei-Wei Zhang Liu-Wei Gu Qing-Huai Liu 

机构地区：[1]Department of Ophthalmology,Jiangsu Province Hospital,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Women and Children Health Hospital,Nanjing 210029,Jiangsu Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2025年第2期315-322,共8页国际眼科杂志(英文版)

基　　金：Supported by the National Natural Science Foundation of China(No.82271100);the Jiangsu Science and Technology Support Program(No.BE2022805);the Clinical Skills Enhancement Program of Jiangsu Province Hospital(No.JSPH-MC-2022-24).

摘　　要：AIM:To assess the visual electrophysiological outcomes in children with functional amblyopia who exhibited poor response to conventional treatment.METHODS:Twenty-one children with functional amblyopia,aged 5.7±2.1y(range:4-10y),underwent comprehensive ophthalmic and refractive evaluations.Spectral domain-optical coherence tomography(SD-OCT)and multifocal electroretinography(mfERG)were conducted to analyze the macular retinal thickness and the first-order response P1 ring of the mfERG in the amblyopic eye(AE)compared to the fellow good eye(GE).RESULTS:Initially,visual acuity in the AE ranged from 20/800 to 20/40,while the GE exhibited a range of 20/25 to 20/20(P<0.01).After 6mo of treatment,17 patients demonstrated improved visual acuity in the AE to 20/50 or better,while 4 children showed no improvement.SD-OCT revealed comparable macular and optic disc structures between the AE and GE.Prior to treatment,the mfERG P1 ring amplitude was significantly reduced in the AE compared to GE(P<0.05).The AE/GE ratio of P1 ring amplitude showed significant improvement post-treatment.However,a smaller AE/GE ratio before treatment was associated with poorer improvement post-treatment.CONCLUSION:In the management of functional amblyopia,a thorough assessment of amblyopic eye examinations is crucial.Approximately 20%of amblyopic eyes may not achieve significant improvement in visual acuity,despite the absence of detectable organic retinal abnormalities.mfERG may reveal underlying abnormalities.Integrating mfERG into initial assessments or treatment follow-ups can aid in identifying potential hidden retinal defects and predicting the prognosis of the amblyopic eye.

关 键 词：functional amblyopia poor response optical coherence tomography multifocal electroretinography retinal defects 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]