养血润目方治疗蒸发过强型干眼的疗效观察  

Observation on the Therapeutic Effect of Yangxue Runmu Prescription in the Treat⁃ment of Evaporative Dry Eye

作　　者：李卓 亢泽峰[1] 袁慧艳 刘洁[1] 张励[1] 李书娇 闫月飞 刘健[1] LI Zhuo;KANG Zefeng;LIU Jian;YUAN Huiyan;LIU Jie;ZHANG Li;LI Shujiao;YAN Yuefei(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,北京100040

出　　处：《中国中医眼科杂志》2025年第2期127-131,共5页China Journal of Chinese Ophthalmology

基　　金：中国中医科学院自主选题课题(ZZ0908017)。

摘　　要：目的观察养血润目方治疗蒸发过强型干眼的临床疗效及安全性。方法纳入2021年12月—2022年12月中国中医科学院眼科医院诊治的蒸发过强型干眼患者80例(160只眼),证属肝血不足证。随机分为对照组和试验组各40例(80只眼)。对照组予睑板腺按摩联合0.1%玻璃酸钠滴眼液治疗,试验组予睑板腺按摩联合养血润目方颗粒剂治疗。2组均治疗1个月。分别于治疗前、治疗后记录受试者的干眼指标和中医证候积分,并做统计分析。结果(1)干眼指标:治疗前后比较,2组治疗后泪膜破裂时间(BUT)均较治疗前延长(t试验组=11.659、t对照组=4.190,均P=0.000),2组治疗后泪液分泌试验(SⅠT)均较治疗前延长(t试验组=22.258、t对照组=9.469,均P=0.000),2组治疗后角膜荧光染色(FL)均较治疗前下降(t试验组=13.476、t对照组=4.108,均P=0.000),差异均有统计学意义。治疗后2组间比较,试验组治疗后BUT、SⅠT均长于对照组,FL低于对照组,差异均有统计学意义(tBUT=5.747、tSⅠT=9.190、tFL=7.044,均P=0.000)。(2)中医证候积分:治疗前后比较,试验组治疗后中医证候积分较治疗前降低,差异有统计学意义(t=14.592,P=0.000);对照组治疗后中医证候积分与治疗前比较,差异无统计学意义(P>0.05)。治疗后2组间比较,试验组治疗后中医证候积分低于对照组,差异有统计学意义(t=10.074,P=0.000)。(3)临床疗效:试验组总有效率为95.00%,高于对照组的70.00%,差异有统计学意义(χ^(2)=17.316,P=0.000)。(4)不良反应:治疗期间2组均未发生不良事件。结论养血润目方口服可有效改善蒸发过强型干眼患者的主观症状及客观检验指标,且具有良好的安全性,值得临床进一步研究并推广。OBJECTIVE To observe the clinical efficacy and safety of Yangxue Runmu Prescription in the treatment of evaporative dry eye.METHODS A total of 80 patients(160 eyes)with hyperevaporative dry eye diagnosed and treated in the Eye Hospital,China Academy of Chinese Medical Sciences from December 2021 to December 2022 were included,and the syndrome was liver blood deficiency.The patients were randomly divided into control group(CG)and experimental group(EG)with 40 cases(80 eyes).The control group was treated with meibomian gland massage combined with 0.1%sodium hyaluronate eye drops,while the experimental group received meibomian gland massage combined with Yangxue Runmu Prescription granules.Both groups were treated for one month.Dry eye indicators and Traditional Chinese Medicine(TCM)syndrome scores were recorded before and after treatment,and statistical analysis was performed.RESULTS(1)Dry eye indicators:Compared with before treatment,the tear film break-up time(BUT)after treatment was prolonged in both groups(tEG=11.659,tCG=4.190,both P=0.000);The SchirmerⅠtest(SⅠT)after treatment was also prolonged in both groups(tEG=22.258,tCG=9.469,both P=0.000).The corneal fluorescein staining(FL)scores after treatment were lower than those before treatment in both groups(tEG=13.476,tCG=4.108,both P=0.000),with statistically significant differences.After treatment,the BUT and SⅠT were longer,and the FL scores were lower in the experimental group compared with the control group,with statistically significant differences(tBUT=5.747,tSⅠT=9.190,tFL=7.044,all P=0.000).(2)TCM syndrome scores:Compared with before treatment,the TCM syndrome scores after treatment were lower in the experimental group,with a statistically significant difference(t=14.592,P=0.000).There was no statistically significant difference in TCM syndrome scores between before and after treatment in the control group(P>0.05).After treatment,the TCM syndrome scores were lower in the experimental group compared with the control group,with a statistically sign

关 键 词：干眼 养血润目方 临床疗效 

分 类 号：R774.1[医药卫生—眼科] R276.7[医药卫生—临床医学]