老年精神分裂症患者出现医院感染的危险因素  

The risk factors of hospital infection in elderly schizophrenic patients

作　　者：汪学翠 马毓 王卓樱 WANG Xuecui;MA Yu;WANG Zhuoying(Suzhou Guangji Hospital Geriatric Psychiatry Department,Suzhou 215000,China)

机构地区：[1]苏州市广济医院老年精神科,苏州215000

出　　处：《国际精神病学杂志》2024年第6期1733-1736,共4页Journal Of International Psychiatry

基　　金：苏州市“科教兴卫”青年科技项目(编号:KJXW2022051)。

摘　　要：目的 探讨老年精神分裂症患者出现医院感染的危险因素。方法 回顾性分析2020年4月~2023年3月本院收治的198例老年精神分裂症患者的临床资料,根据住院期间是否发生医院感染分为未感染组(n=143)与感染组(n=55)。比较两组一般资料[性别、年龄、病程、住院次数、住院时间、阳性和阴性症状量表(Positive and Negative Syndrome,PANSS)、是否使用2种及以上抗精神病药物、长期应用抗菌药物]及一氧化氮(Nitric Oxide,NO)、过氧化氢酶(Catalase,CAT)、总抗氧化能力(Total Antioxidant Capacity,T-AOC)、谷胱甘肽过氧化物酶(Glutathione Peroxidase,GSHPx)间的差异,经多因素Logistic回归分析老年精神分裂症患者发生医院感染的危险因素。结果 未感染组使用2种及以上抗精神病药物、长期应用抗菌药物占比以及PANSS评分、NO水平低于感染组,CAT、GSH-Px、T-AOC水平高于感染组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,PANSS评分、使用2种及以上抗精神病药物、长期应用抗菌药物、血清CAT、GSHPx、T-AOC、NO水平是老年精神分裂症患者发生医院感染的危险因素,P<0.05。结论 老年精神分裂症患者发生医院感染受PANSS评分、使用2种及以上抗精神病药物、长期应用抗菌药物、血清CAT、GSH-Px、T-AOC、NO水平影响,应予以密切关注。Objective To explore the risk factors of hospital infection in elderly patients with schizophrenia.Methods A retrospective analysis was conducted on the clinical data of 198 elderly patients with schizophrenia admitted to our hospital from April 2020 to March 2023.They were divided into an uninfected group(n=143)and an infected group(n=55)based on whether hospital infections occurred during hospitalization.Compare two sets of general information [gender,age,course of disease,number of hospitalizations,length of stay,Positive and Negative Symptom Scale(PANSS),use of two or more antipsychotic drugs,long-term use of antibiotics],as well as nitric oxide(NO),catalase(CAT),total antioxidant capacity(T-AOC)The differences in glutathione peroxidase(GSH-Px)levels were analyzed using multivariate logistic regression to identify the risk factors for hospital acquired infections in elderly patients with schizophrenia.Results The results showed that the non infected group used two or more antipsychotic drugs,the proportion of long-term use of antibiotics,PANSS score,and NO level were lower than those of the infected group,while the levels of CAT,GSH-Px,and T-AOC were higher than those of the infected group,with statistical significance(P<0.05).The results of multivariate logistic regression analysis showed that PANSS score,use of two or more antipsychotic drugs,long-term use of antibiotics,serum CAT,GSH-Px,T-AOC,and NO levels were risk factors for hospital acquired infections in elderly patients with schizophrenia,all with P<0.05.Conclusion The occurrence of hospital infection in elderly schizophrenia patients is influenced by PANSS score,the use of two or more antipsychotic drugs,long-term use of antibiotics,serum CAT,GSH-Px,T-AOC,and NO levels,and should be closely monitored.

关 键 词：精神分裂症 医院感染 氧化应激 总抗氧化能力 一氧化氮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]