VEGF及FGF-2与老年难治性抑郁症患者预后的相关性  

Correlation between VEGF and FGF-2 and prognosis of refractory depression in elderly patients

作　　者：范瑾 徐晓嵘 乔昀 FAN Jin;XU Xiaorong;QIAO Yun(Department of Laboratory,Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital(West Hospital),Shanghai 200021,China)

机构地区：[1]上海市中医药大学附属曙光医院(西院)检验科,上海200021

出　　处：《国际精神病学杂志》2024年第6期1776-1780,共5页Journal Of International Psychiatry

摘　　要：目的 探讨血管内皮生长因子(Vascular endothelial growth factor,VEGF)及成纤维细胞生长因子-2(Fibroblast growth factor-2,FGF-2)与老年难治性抑郁症患者预后的关系。方法 选取我院2019年7月~2022年7月收治的老年难治性抑郁症患者100例,根据随访结果将其分为预后不良组(n=38)及预后良好组(n=62)。收集患者一般资料,分析老年难治性抑郁症患者预后不良的危险因素及VEGF、FGF-2预测老年难治性抑郁症患者预后不良的价值。结果 预后不良组艾森克个性问卷(Eysenck Personality Questionnaire,EPQ)标准分N维度分值、有慢性躯体疾病人数占比显著高于预后良好组,预后不良组社会支持评定量表(Social Support Rating Scale,SSRS)总分、VEGF、FGF-2水平显著低于预后良好组(P<0.05)。多因素Logistic回归分析提示,EPQ标准分N维度分值、慢性躯体疾病、SSRS总分、VEGF、FGF-2是老年难治性抑郁症患者预后不良的危险因素(P<0.05)。ROC曲线分析结果显示,VEGF、FGF-2预测老年难治性抑郁症患者预后不良的曲线下面积分别为0.724、0.820,且P<0.05。结论 EPQ标准分N维度分值、慢性躯体疾病、SSRS总分、VEGF、FGF-2是老年难治性抑郁症患者预后不良的危险因素,临床需格外注意。Objective To investigate the relationship between vascular endothelial growth factor(Vascular endothelial growth factor,VEGF)and fibroblast growth factor-2(Fibroblast growth factor-2,FGF-2)and prognosis of elderly patients with treatment-resistant depression.Methods A total of 100 elderly patients with treatment-resistant depression admitted to our hospital from July 2019 to July 2022 were selected and divided into poor prognosis group(n = 38)and good prognosis group(n = 62)according to the follow-up results.General data were collected to analyze the risk factors of poor prognosis in elderly patients with refractory depression and the value of VEGF and FGF-2 in predicting poor prognosis in elderly patients with refractory depression.Results The Eysenck Personality Questionnaire(Eysenck Personality Questionnaire,EPQ)standard score of N dimension and the proportion of people with chronic physical diseases in the poor prognosis group were significantly higher than those in the good prognosis group,while the Social Support Rating Scale(Social Support Rating Scale,SSRS)total score,the levels of VEGF and FGF-2 in the poor prognosis group were significantly lower than those in the good prognosis group(P<0.05).Multivariate Logistic regression analysis confirmed that EPQ standard score of N dimension,chronic physical disease,SSRS total score,VEGF,FGF-2 were the risk factors for poor prognosis in elderly patients with refractory depression(P<0.05).ROC curve analysis results showed that the area under the curve of VEGF and FGF-2 in predicting poor prognosis of elderly patients with refractory depression was 0.724 and 0.820,respectively,and P<0.05.Conclusions EPQ standard N-dimension score,chronic physical disease,SSRS total score,VEGF and FGF-2 are risk factors for poor prognosis in elderly patients with refractory depression,and clinical attention should be paid to them.

关 键 词：难治性抑郁症 血管内皮生长因子 成纤维细胞生长因子-2 预后 

分 类 号：R749.44[医药卫生—神经病学与精神病学]