小剂量奥氮平联合舍曲林对难治性强迫症患者的效果  

The Effect of low-dose Olanzapine combined with Sertraline in treatment of patients with refractory obsessive-compulsive disorder

作　　者：黄文广 程欢迎 李改云 HUANG Wenguang;CHENG Huanying;LI Gaiyun(Xicheng Branch of Luohe Central Hospital,Luohe 462000,China)

机构地区：[1]漯河市中心医院西城分院,漯河462000

出　　处：《国际精神病学杂志》2024年第6期1828-1830,共3页Journal Of International Psychiatry

摘　　要：目的 探讨小剂量奥氮平联合舍曲林治疗难治性强迫症患者的临床疗效。方法 纳入漯河市中心医院2020年7月~2022年7月104例难治性强迫症患者,数字表法随机分为两组。对照组采用舍曲林治疗,观察组采用小剂量奥氮平联合舍曲林治疗。比较两组治疗前后耶鲁-布朗强迫症量表(Yale-Brown obsessive-compulsive Scale,Y-BOCS)、社会功能缺陷筛选量表(Social disability screening schedule,SDSS),评估综合治疗效果,观察不良反应发生情况。结果 治疗后两组患者的Y-BOCS评分、SDSS评分均显著降低(P<0.05),且治疗后观察组各项评分均显著低于对照组(P<0.05);观察组治疗总有效率显著高于对照组(P<0.05);两组不良反应发生率差异无统计学意义(P>0.05)。结论 小剂量奥氮平联合舍曲林治疗难治性强迫症能够进一步降低强迫症状,提升社会功能,并且不增加药物无良反应。Objective To investigate the clinical efficacy of low-dose olanzapine combined with sertraline in the treatment of patients with refractory obsessive-compulsive disorder.Methods A total of 104 patients with refractory obsessive-compulsive disorder were included in Luohe Central Hospital from July 2020 to July 2022,and were randomly divided into two groups by numerical table method.The control group was treated with sertraline,and the observation group was treated with low-dose olanzapine combined with sertraline.Yale-Brown Obsessive-Compulsive Scale(Y-BOCS),Social disability screening schedule(SDSS)were compared between the two groups before and after treatment.The comprehensive treatment effect was assessed and the occurrence of adverse reactions was observed.Results Y-BOCS scores,and SDSS scores were significantly lower in both groups after treatment(P<0.05).And all scores of the observation group were significantly lower than the control group after treatment(P<0.05).The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusion Low-dose olanzapine in combination with sertraline for treatment of refractory obsessive-compulsive disorder can further reduces obsessive-compulsive symptoms,improves psychological status,and does not increase drug adverse reactions.

关 键 词：小剂量奥氮平 舍曲林 难治性强迫症 社会功能 不良反应 

分 类 号：R749.05[医药卫生—神经病学与精神病学]