冠心病合并抑郁患者对冠状动脉斑块成分及稳定性的影响  

Effect of Coronary Artery Disease Combined with Depressed Patients on Coronary Plaque Composition and Stability

作　　者：金峰 季帅 郭兴 祁昊 JIN Feng;JI Shuai;GUO Xing(South Campus of Henan Chest Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省胸科医院南院区,郑州450000

出　　处：《国际精神病学杂志》2024年第6期1883-1885,共3页Journal Of International Psychiatry

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20190738)。

摘　　要：目的 探讨冠心病合并抑郁患者对冠状动脉斑块成分、性质及稳定性的影响。方法 纳入2021年1月~2023年8月98例冠心病患者,对患者进行抑郁情绪评估,并根据评估结果划分为抑郁与无抑郁组,分别为26例、72例。比较两组患者冠状动脉斑块成分、性质及稳定性。结果抑郁组斑块中坏死核心占比显著高于非抑郁组,(t=8.927,P<0.001),纤维脂肪、钙化、纤维组织差异无统计学意义(t=1.593,P=0.114;t=1.295,P=0.199;t=0.929,P=0.335);抑郁组纤维帽厚度低于非抑郁组,斑块角度、易损性斑块占比高于非抑郁组,(t=3.956,P<0.001;t=5.261,P<0.001;t=6.496,P<0.001),组间斑块长度差异无统计学意义(t=0.500,P=0.618)。结论 冠心病合并抑郁较为常见,且抑郁患者冠状动脉斑块成分中坏死核心组织以及易损性斑块含量较多,斑块稳定性更差。Objective To investigate the effects of coronary artery disease combined with depression in patients with coronary artery disease on coronary plaque composition,properties and stability.Methods Ninety-eight patients with coronary artery disease were included from January 2021 to August 2023,and the patients were assessed for depressed mood.And according to the assessment results,they were divided into depression and no depression groups,26cases and 72 cases respectively.Coronary plaque composition,nature and stability were compared between the two groups.Results The percentage of necrotic core in plaques was significantly higher in the depressed group than in the nondepressed group(t=8.927,P<0.001).The differences in fibrofat,calcification,and fibrous tissue were not statistically significant(t=1.593,P=0.114;t=1.295,P=0.199;t=0.929,P=0.335).Fibrous cap thickness was lower in the depressed group than in the non-depressed group,and the percentage of plaque angle and vulnerable plaques was higher than in the non-depressed group(t=3.956,P<0.001;t=5.261,P<0.001;t=6.496,P<0.001).The difference in plaque length between the groups was not statistically significant(t=0.500,P=0.618).Conclusion Depression is more common in combination with coronary artery disease,and depressed patients have more necrotic core tissue as well as vulnerable plaques in their coronary plaque composition,and their plaque stability is worse.

关 键 词：冠心病 抑郁 冠状动脉 斑块成分 斑块性质 斑块稳定性 

分 类 号：R749.92[医药卫生—神经病学与精神病学]