冠心病伴抑郁患者血清Adropin、PAF、GFAP水平与抑郁严重程度的关系及预测价值  

Relationship between Serum Adropin,PAF,GFAP Levels and Depression Severity in Patients with Coronary Heart Disease and Their Predictive Value

作　　者：惠玲玲[1] 闫妮 杨利娟 HUI Lingling;YAN Ni;YANG Lijuan(Cardiology Department 2 of Xi'an High tech Hospital,Xian 710075,China)

机构地区：[1]西安高新医院心内二科,西安710075 [2]陕西省人民医院内分泌科

出　　处：《国际精神病学杂志》2024年第6期1886-1890,1896,共6页Journal Of International Psychiatry

基　　金：国家自然科学基金资助项目(编号:82100830)。

摘　　要：目的 分析冠心病(Coronary Heart Disease,CHD)伴抑郁情绪患者血清脂联素调节蛋白(serum Adropin,Adropin)、血小板活化因子(Platelet-Activating Factor,PAF)、胶质纤维酸性蛋白(Glial fibrillary acidic protein,GFAP)水平与患者抑郁症严重程度的关系及预测价值。方法2022年1月~2023年12月期间,选取86例CHD伴抑郁患者,按汉密尔顿抑郁量表(HAMD-17)评分分为轻度36例、中度31例、重度19例。比较各组血清Adropin、PAF、GFAP及HAMD-17评分,分析相关性及血清标志物对CHD抑郁严重程度的预测价值。结果 与轻度组相比,中、重度组血清Adropin低(P<0.05),PAF、GFAP及HAMD-17评分高(P<0.05)。重度组Adropin更低,其他指标更高(P<0.05)。Pearson分析示:Adropin与抑郁负相关(r=-0.484),PAF、GFAP与抑郁正相关(r=0.622、0.649)。中度联合预测AUC为0.515~0.588,敏感度87.1%~100.0%,特异度30.9%~81.8%。重度联合预测AUC为0.881~0.987,敏感度89.5%~94.7%,特异度77.6%~100.0%。结论 CHD伴抑郁情绪患者抑郁程度越高,其血清Adropin越低,血清PAF、GFAP越高,三者联合可提高对重度抑郁的预测价值。Objective Analyze the relationship and predictive value of serum adiponectin regulatory protein(Adropin),platelet activating factor(PAF),glial fibrillary acidic protein(GFAP)levels with the severity of depression in patients with coronary heart disease(CHD)and depression.Methods From January 2022 to December 2023,86 CHD patients with depression were selected and classified according to the Hamilton's Depression Scale(HAMD-17)score into mild 36 cases,moderate 31 cases,and severe 19 cases.Compare the serum Adropin,PAF,GFAP,and HAMD-17 scores of each group,analyze the correlation and predictive value of serum markers for the severity of depression in CHD.Result Compared with the mild group,the serum Adropin levels in the moderate and severe groups were lower(P<0.05),and the PAF,GFAP,and HAMD-17 scores were higher(P<0.05).The severe group had lower levels of Adropin and higher levels of other indicators(P<0.05).Pearson analysis showed that Adropin was negatively correlated with depression(r=-0.484),while PAF and GFAP were positively correlated with depression(r=0.622,0.649).The moderate joint prediction AUC is 0.515-0.588,with a sensitivity of 87.1% ~100.0% and a specificity of 30.9% ~81.8%.The severe combined prediction AUC is 0.881~0.987,with a sensitivity of 89.5%~94.7% and a specificity of 77.6% ~100.0%.Conclusion The higher the degree of depression in patients with coronary heart disease and depression,the lower their serum Adropin,and the higher their serum PAF and GFAP.The combination of the three can improve the predictive value for severe depression.

关 键 词：冠心病 抑郁症 血小板活化因子 胶质纤维酸性蛋白 

分 类 号：R749.92[医药卫生—神经病学与精神病学]