抗VEGF药物治疗对糖尿病黄斑水肿患者焦虑及应对方式的影响  

Anxiety of diabetic macular edema patients in anti-VEGF drug treatment and its influence on their coping style

作　　者：李曼[1] 廖周鹏 谢海娟[1] LI Man;LIAO Zhoupeng;XIE Haijuan(Ophthalmology Department of Baoji People's Hospital in Shaanxi Province,Baoji 721000,China)

机构地区：[1]陕西省宝鸡市人民医院眼三科,宝鸡721000

出　　处：《国际精神病学杂志》2024年第6期1920-1925,共6页Journal Of International Psychiatry

基　　金：陕西省科学技术研究发展计划项目(编号:S2016YF0388)。

摘　　要：目的探讨抗血管内皮生长因子(vascular endothelial growth factor,VEGF)药物治疗对糖尿病黄斑水肿(diabetic macular edema,DME)患者焦虑及应对方式的影响。方法2020年1月~2023年9月期间,选取80例DME患者,采用状态焦虑量表(State anxiety inventory,S-AI)、医学应对问卷(Medical Coping Modes Questionnaire,MCMQ)评估DME患者的焦虑状态、应对方式,比较不同临床特征患者的S-AI评分,并分析DME患者状态焦虑的影响因素,S-AI与MCMQ各维度评分的相关性,以及MCMQ各维度评分的影响因素。结果年龄30~70岁、>70岁患者的S-AI评分高于年龄≤30岁患者(P<0.05),年龄>70岁患者的S-AI评分高于年龄30~70岁患者(P<0.05),女性、糖尿病病程>5年、自费/城乡居民医保、农村、双眼患者的S-AI评分高于与之对应的男性、糖尿病病程≤5年、省/市医保、城镇、单眼患者(P<0.05)。经线性回归分析,年龄、支付方式、面对负向影响患者的S-AI评分(P<0.05),回避正向影响患者的S-AI评分(P<0.05)。经Pearson分析,S-AI评分与MCMQ的面对维度评分呈负相关(P<0.05),与MCMQ的回避、屈服维度评分呈正相关(P<0.05)。经线性回归分析,S-AI评分负向影响患者的MCMQ的面对维度评分(P<0.05),S-AI评分正向影响患者的MCMQ的回避、屈服维度评分(P<0.05)。结论抗VEGF药物治疗中的DME患者状态焦虑较高,年龄、支付方式、MCMQ中的面对和回避维度是其影响因素,且状态焦虑对DME患者的应对方式具有影响。Objective To explore the state anxiety of(diabetic macular edema,DME)patients treated with anti-vascular endothelial growth factor(VEGF)drugs and its influence on their coping style.Methods From January 2020 to September 2023,80 DME patients were selected,and the state anxiety and coping style of DME patients were evaluated by using State anxiety inventory,(S-AI)and Medical Coping Modes Questionnaire(MCMQ).Compare the S-AI scores of patients with different clinical characteristics,and analyze the influencing factors of state anxiety of DME patients,the correlation between S-AI and MCMQ scores,and the influencing factors of MCMQ scores.Results The S-AI scores of patients aged 30~70 years and over were higher than those of patients aged 30≤(P<0.05),while those of patients aged over 70 years were higher than those of patients aged 30~70 years(P<0.05).Women,patients with diabetes mellitus>5 years,self-funded/urban and rural residents'medical insurance,rural and binocular patients.According to linear regression analysis,age,payment method and face negatively affected the S-AI score of patients(P<0.05),but avoided positively influencing the S-AI score of patients(P<0.05).According to Pearson analysis,the S-AI score was negatively correlated with MCMQ's face dimension score(P<0.05),and positively correlated with MCMQ's avoidance and yield dimension score(P<0.05).According to linear regression analysis,S-AI score negatively affected the face dimension score of patients'MCMQ(P<0.05),while S-AI score positively affected the avoidance and yield dimension score of patients'MCMQ(P<0.05).Conclusion The state anxiety of DME patients in anti-VEGF drug therapy is high,and the influencing factors are age,payment method and the dimensions of facing and avoiding in MCMQ,and the state anxiety has an influence on the coping style of DME patients.

关 键 词：糖尿病黄斑水肿 血管内皮生长因子 焦虑状态 应对方式 影响因素 

分 类 号：R749[医药卫生—神经病学与精神病学]