Effects of probiotic treatment on the prognosis of patients with sepsis: a systematic review  

作　　者：Chao Gong Shengyong Xu Youlong Pan Shigong Guo Joseph Harold Walline Xue Wang Xin Lu Shiyuan Yu Mubing Qin Huadong Zhu Yanxia Gao Yi Li 

机构地区：[1]Emergency Department,the State Key Laboratory for Complex,Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China [2]Emergency Department,Qinghai Cardio-cerebrovascular Specialty Hospital,Xining 810012,China [3]Department of Rehabilitation Medicine,Southmead Hospital,Bristol BS105NB,UK [4]Department of Emergency Medicine,Milton S.Hershey Medical Center,the Pennsylvania State University,Hershey 17033,USA [5]Department of Allergy&Clinical Immunology,Peking Union Medical College Hospital,Peking Union Medical College&Chinese Academy of Medical Sciences,National Clinical Research Center for Immunologic Diseases,Beijing 100730,China [6]Emergency Department,the First Affi liated Hospital of Zhengzhou University,Zhengzhou 450052,China

出　　处：《World Journal of Emergency Medicine》2025年第1期18-27,共10页世界急诊医学杂志(英文)

基　　金：supported by the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-109);Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFMS)(2021-I2M-1-020)。

摘　　要：BACKGROUND: Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their effects are stil inconclusive. This study aimed to evaluate the overal eff ect of probiotics on the prognosis of patients with sepsis.DATA RESOURCES: We searched several sources for published/presented studies, including Pub Med, EMBASE, Web of Science, the Cochrane Library and the US National Library of Medicine Clinical Trials Register(www.clinicaltrials.gov) updated through July 30, 2023, to identify all relevant randomized controlled trials(RCTs) or observational studies that assessed the effectiveness of probiotics or synbiotics in patients with sepsis and reported mortality. We focused primarily on mortality during the study period and analyzed secondary outcomes, including 28-day mortality, in-intensive care unit(ICU) mortality and other outcomes.RESULTS: Data from 405 patients in five RCTs and 108 patients in one cohort study were included in the analysis. The overall quality of the studies was satisfactory, but clinical heterogeneity existed. All adult studies reported a tendency for probiotics to reduce the mortality of patients with sepsis, and most studies reported a decreasing trend in the incidence of infectious complications, length of ICU stay and duration of antibiotic use. There was only one RCT involving children.CONCLUSION: Probiotics show promise for improving the prognosis of patients with sepsis, including reducing mortality and the incidence of infectious complications, particularly in adult patients. Despite the limited number of studies, especially in children, these findings will be encouraging for clinical practice in the treatment of sepsis and suggest that gut microbiota-targeted therapy may improve the prognosis of patients with sepsis.

关 键 词：SEPSIS PROBIOTICS SYNBIOTICS MORTALITY Gut microbiota 

分 类 号：R73[医药卫生—肿瘤]