Application of myxovirus resistance protein A in the etiological diagnosis of infections in adults  

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作  者:Tianpeng Hu Yan Li Shengtao Yan Lichao Sun Rui Lian Jieqiong Yu Jie Chen Xiaoyu Liu Guoqiang Zhang 

机构地区:[1]Department of Emergency Medicine,China-Japan Friendship Hospital,Beijing 100029,China [2]Graduate School,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China

出  处:《World Journal of Emergency Medicine》2025年第1期35-42,共8页世界急诊医学杂志(英文)

基  金:supported by the National Natural Science Foundation of China (82272196 and 82272220)。

摘  要:BACKGROUND: Inappropriate antibiotic treatment for patients with viral infections has led to a surge in antimicrobial resistance, increasing mortality and healthcare costs. Viral and bacterial infections are often difficult to distinguish. Myxovirus resistance protein A(MxA), an essential antiviral factor induced by interferon after viral infection, holds promise for distinguishing between viral and bacterial infections. This study aimed to determine the ability of Mx A to distinguish viral from bacterial infections.METHODS: We quantified MxA in 121 infected patients via dry immunofluorescence chromatography. The Kruskal-Wallis test and receiver operating characteristic(ROC) curve analysis were used to determine the diagnostic value of Mx A, either alone or in combination with C-reactive protein(CRP) or procalcitonin(PCT), in patients with viral, bacterial, or co-infections.RESULTS: The value of MxA(ng/mL) was significantly higher in patients with viral infections than in those with bacterial and co-infections(82.3 [24.5–182.9] vs. 16.4 [10.8–26.5], P<0.0001)(82.3 [24.5–182.9] vs. 28.5 [10.2–106.8], P=0.0237). The area under the curve(AUC) of the ROC curve for distinguishing between viral and bacterial infections was 0.799(95% confidence interval [95% CI] 0.696–0.903), with a sensitivity of 68.9%(95% CI 54.3%–80.5%) and specificity of 90.0%(95% CI 74.4%–96.5%) at the threshold of 50.3 ng/mL. Combining the MxA level with the CRP or PCT level improved its ability. MxA expression was low in cytomegalovirus(15.8 [9.6–47.6] ng/mL) and Epstein-Barr virus(12.9 [8.5–21.0] ng/mL) infections.CONCLUSION: Our study showed the diagnostic efficacy of Mx A in distinguishing between viral and bacterial infections, with further enhancement when it was combined with CRP or PCT. Moreover, EpsteinBarr virus and human cytomegalovirus infections did not elicit elevated Mx A expression.

关 键 词:Myxovirus resistance protein A Viral infections C-reactive protein PROCALCITONIN BIOMARKER 

分 类 号:R446.5[医药卫生—诊断学]

 

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