Adult split liver transplantation to treat liver cancer: a single-center retrospective study  

作　　者：Qiang Sun Haoze Cao Xuesong Bai Xin Han Wanlu You Zhongquan Sun Yixin Zhang Xiaochang Wu Feng Fang Fan Wu Lianyue Yang Sheng Yan Yuan Ding Weilin Wang 

机构地区：[1]Department of Hepatobiliary Pancreatic Surgery,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China [2]Department of Hepatobiliary Surgery,Huzhou Central Hospital,Zhejiang University Huzhou Hospital,Huzhou 313002,China [3]Department of General Surgery,Xiangya Hospital,Central South University,Changsha 410008,China

出　　处：《World Journal of Emergency Medicine》2025年第1期57-62,共6页世界急诊医学杂志(英文)

基　　金：Key Project of Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province (GZY-ZJ-KJ-24077);National Natural Science Foundation of China (No. U23A202181, 8207101520, 82272860);Central Guidance on Local Science and Technology Development Fund of Zhejiang Province (2023ZY1017);Fundamental Research Funds for the Central Universities (No. 226-2023-00038);Special Financial Support for Zhejiang Traditional Chinese Medicine Innovation Teams。

摘　　要：BACKGROUND: The increasing morbidity of liver cancer has led to a growing demand for transplantation. Split liver transplantation(SLT) is a promising way to ameliorate organ shortages. However, the safety and efficacy of SLT are still controversial. The aim of this study was to assess the clinical outcome of SLT in liver cancer patients at our center. METHODS: A total of 74 patients who received liver transplantation at a tertiary hospital from March 2019 to July 2023 were retrospectively studied, of whom 37 recipients underwent SLT and 37 recipients underwent whole-graft liver transplantation(WGLT). Clinical data were analyzed and compared between patients who underwent SLT and WGLT.RESULTS: SLT and WGLT were successfully performed, with no intraoperative transplantrelated mortality. Postoperatively, no significant differences in total bilirubin(TB, P=0.266), alanine transaminase(ALT, P=0.403) and aspartate transaminase(AST, P=0.160) levels within 30 d were detected between the two groups. The transplant-related mortality rates were 8.1% in the SLT group and 5.4% in the WGLT group within 30 d of surgery(P=1.000), and 10.8% and 8.1%, respectively, at 90 d after surgery(P=1.000). There were no significant differences in overall survival(OS) and progress-free survival(PFS) between the SLT and WGLT groups(P=0.910, P=0.190). CONCLUSION: Our results show that SLT does not imply additional risks in treating liver cancer compared with WGLT.

关 键 词：ADULT Split liver transplantation Liver cancer PROGNOSIS RETROSPECTIVE 

分 类 号：R735.7[医药卫生—肿瘤]