乳酸及组蛋白乳酰化在疾病中的调控作用机制  

The regulatory mechanisms of lactic acid and histone lactylation in diseases

作　　者：杨淑洁 沈艳 YANG Shujie;SHEN Yan(Medical School of Nantong University,Jiangsu 226001;Department of Intensive Care Unit,the People's Hospital of Rugao;Department of Emergency Medicine,Affiliated Hospital of Nantong University)

机构地区：[1]南通大学医学院,江苏226001 [2]如皋市人民医院重症医学科 [3]南通大学附属医院急诊科

出　　处：《南通大学学报(医学版)》2024年第6期561-565,共5页Journal of Nantong University(Medical sciences)

基　　金：国家自然科学基金资助项目(802000632)。

摘　　要：乳酸自发现以来一直被认为是缺氧产生的糖酵解废物。乳酸是代谢过程中的重要中间体,作为生物功能调节因子,通过“乳酸穿梭”方式参与肿瘤、炎症、创伤修复等疾病过程。乳酸作为信号分子还参与多种表观遗传修饰,如组蛋白乳酰化修饰。组蛋白乳酰化修饰可促进巨噬细胞从经典活化型(M1型)向替代活化型(M2型)转化,参与多种疾病的发生发展,包括肿瘤增殖、神经兴奋、炎症损伤等。本研究对乳酸及组蛋白乳酰化的研究进展进行综述,为今后的研究提供参考和方向。Since its discovery,lactate has traditionally been considered a byproduct of glycolysis under hypoxic conditions.However,lactate is now recognized as a crucial metabolic intermediate that acts as a biological regulatory factor,participating in various disease processes(such as tumors,inflammation,and wound healing)through the mechanism of“lactate shuttle”.In addition,lactate functions as a signaling molecule and plays a role in multiple epigenetic modifications,including histone lactylation.Histone lactylation can facilitate the transformation of macrophages from the classically activated(M1)phenotype to the alternatively activated(M2)phenotype,thereby contributing to the progression of various diseases,including tumor proliferation,neuronal excitation,and inflammatory injury etc.This review summarizes the recent advances in the study of lactate and histone lactylation,aiming to provide insights and directions for future research.

关 键 词：乳酸 乳酸穿梭 组蛋白乳酰化 癌症 巨噬细胞 

分 类 号：Q591[生物学—生物化学]