高分辨率CT联合血清表皮生长因子受体、肿瘤转移性相关基因1鉴别多原发肺腺癌及肺腺癌伴肺内转移的价值  

Value of high-resolution CT combined with serum EGFR and MTA1 in distinguishing multiple primary lung adenocarcinoma and lung adenocarcinoma with intrapulmonary metastasis

作　　者：寇介丽 刘娜 杨枫 刘桃桃 李丹萍 韩君蕊 杨立洲 KOU Jieli;LIU Na;YANG Feng;LIU Taotao;LI Danping;HAN Junrui;YANG Lizhou(Department of CT Radiology,Cangzhou People’s Hospital,Cangzhou 061000,China)

机构地区：[1]河北省沧州市人民医院CT放射科,061000

出　　处：《临床外科杂志》2024年第12期1259-1263,共5页Journal of Clinical Surgery

基　　金：河北省沧州市重点研发计划指导项目(222106039)。

摘　　要：目的 探讨高分辨率CT联合血清表皮生长因子受体(EGFR)、肿瘤转移性相关基因1(MTA1)鉴别多原发肺腺癌及肺腺癌伴肺内转移的价值。方法 选取2020年10月~2022年10月本院收治的多原发肺腺癌病人56例作为多原发肺腺癌组,同期收治的47例肺腺癌伴肺内转移病人作为肺腺癌伴肺内转移组,同时期的50例健康体检者为对照组。比较多原发肺腺癌病人与肺腺癌伴肺内转移病人的基本资料;比较对照组、多原发肺腺癌组与肺腺癌伴肺内转移组血清EGFR和MTA1水平;比较多原发肺腺癌组与肺腺癌伴肺内转移组的影像配对类型、主病灶与伴随病灶的影像学特征;采用受试者工作特征(ROC)曲线分析高分辨率CT联合血清EGFR,MTA1鉴别多原发肺腺癌及肺腺癌伴肺内转移的价值。结果 多原发肺腺癌组与肺腺癌伴肺内转移组病人的年龄比较,差异无统计学意义(P>0.05),但肺腺癌伴肺内转移组中男性占比和有吸烟史者占比显著高于多原发肺腺癌组,差异有统计学意义(P<0.05);肺腺癌伴肺内转移组病人血清EGFR、MTA1水平高于多原发肺腺癌组和对照组,差异有统计学意义(P<0.05);多原发肺腺癌组与肺腺癌伴肺内转移组病人的影像配对类型中,纯磨玻璃结节、混合磨玻璃结节、实性结节、纯磨玻璃结节+混合磨玻璃结节、纯磨玻璃结节+实性结节、混合磨玻璃结节+实性结节比较,差异均有统计学意义(P<0.05);多原发肺腺癌组与肺腺癌伴肺内转移组病人主病灶有无磨玻璃成分以及空泡比较,差异有统计学意义(P<0.05),两组病人伴随病灶中形态、边界清晰与否、有无磨玻璃成分、分叶和空泡对病人伴随病灶的影响显著(P<0.05);ROC曲线显示高分辨率CT、血清EGFR、MTA1单独和联合鉴别多原发肺腺癌及肺腺癌伴肺内转移的曲线下面积(AUC)分别为0.819、0.778、0.826、0.908,三者联合鉴别价值优于单独鉴别(Z_(三者联合-高分辨�Objective To explore the value of high-resolution CT combined with serum epidermal growth factor receptor(EGFR)and metastasis associated gene 1(MTA1)in distinguishing multiple primary lung adenocarcinoma and lung adenocarcinoma with intrapulmonary metastasis.Methods From October 2020 to October 2022,56 patients with multiple primary lung adenocarcinoma accepted by our hospital were regarded as the multiple primary lung adenocarcinoma group,47 patients with lung adenocarcinoma and intrapulmonary metastasis admitted to our hospital were as the lung adenocarcinoma and intrapulmonary metastasis group,and 50 healthy individuals were as the control group.The basic data of multiple primary lung adenocarcinoma patients and lung adenocarcinoma patients with intrapulmonary metastasis were collected,organized,and compared;the serum EGFR and MTA1 levels were compared between the control group,multiple primary lung adenocarcinoma patients,and lung adenocarcinoma patients with intrapulmonary metastasis;the imaging matching types of multiple primary lung adenocarcinoma patients and lung adenocarcinoma patients with intrapulmonary metastasis were compared;the imaging features of the main and accompanying lesions in the two groups were compared;receiver operating characteristic(ROC)curve was applied to analyze the value of high-resolution CT combined with serum EGFR and MTA1 in distinguishing multiple primary lung adenocarcinoma and lung adenocarcinoma with intrapulmonary metastasis.Results There was no significant difference in age between patients with multiple primary lung adenocarcinoma and those with lung adenocarcinoma with intrapulmonary metastasis(P>0.05),however,the proportion of males and those with a history of smoking in lung adenocarcinoma and intrapulmonary metastasis group was obviously higher than that in multiple primary lung adenocarcinoma group(P<0.05);the levels of serum EGFR and MTA1 in patients with lung adenocarcinoma and intrapulmonary metastasis were obviously higher than those in the multiple primary lun

关 键 词：多原发肺腺癌 肺腺癌伴肺内转移 表皮生长因子受体 肿瘤转移性相关基因1 

分 类 号：R73[医药卫生—肿瘤]