肝切除术中应用Pringle法血流阻断对肝细胞癌病人预后的影响  

Effect of Pringle maneuver on prognosis of patients with hepatocellular carcinoma during hepatectomy

作　　者：谢镇徽 黄志勇[1] XIE Zhenhui;HUANG Zhiyong(Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院肝脏外科中心,武汉430030

出　　处：《临床外科杂志》2024年第12期1340-1342,共3页Journal of Clinical Surgery

摘　　要：肝细胞癌是我国发病率排名第五的常见恶性肿瘤,肝切除术是目前治疗肝细胞癌的主要方式之一。Pringle法血流阻断(Pringle maneuver,PM)已被广泛应用于肝切除术以减少出血,但该操作会引起肝脏缺血再灌注损伤,长时间使用PM可能影响肝脏功能,增加术后并发症,尤其在肝硬化病人中更为明显。PM可加快肝内微转移灶肿瘤细胞的生长,促进肿瘤转移。但PM安全使用时限、方式及其是否会缩短肝癌肝切除术病人的无病生存期或总生存期,尚存在争议。现对肝切除术中应用Pringle法血流阻断对肝细胞癌病人预后的影响进行综述。Hepatocellular carcinoma is the fifth most common malignant tumor in our country,and hepatectomy is one of the main treatment methods for hepatocellular carcinoma.Pringle maneuver(PM)is widely used in hepatectomy to reduce bleeding,but the maneuver causes ischemia reperfusion injury.Prolonged use of PM may affect liver function and increase postoperative complications,especially in patients with cirrhosis.PM may also accelerate the growth of micrometastatic tumor cells in the liver and promote tumor metastasis.However,the safe duration and methods of PM usage,as well as whether it shortens the disease-free survival or overall survival of patients undergoing liver resection for hepatocellular carcinoma,remain controversial.This article summarizes the effect of Pringle maneuver on the prognosis of patients with hepatocellular carcinoma during hepatectomy.

关 键 词：肝细胞癌 肝切除术 Pringle法血流阻断 预后 

分 类 号：R73[医药卫生—肿瘤]