COX-2、PARP10表达与胃肠胰神经内分泌肿瘤患者预后的相关性研究  

Correlation Study of COX-2 and PARP10 Expression with Prognosis in Patients with Gastroenteropancreatic Neuroendocrine Neoplasms

作　　者：沈雪雯 汤琪云[1] 柏建安 李晓雅 SHEN Xuewen;TANG Qiyun;BAI Jian'an;LI Xiaoya(Department of Geriatric Gastroenterology,The First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)

机构地区：[1]南京医科大学第一附属医院老年消化科,江苏南京210029

出　　处：《转化医学杂志》2024年第9期1305-1309,1314,共6页Translational Medicine Journal

基　　金：国家自然科学基金资助项目(82373180)。

摘　　要：目的探讨胃肠胰神经内分泌肿瘤(GEP-NENs)组织中环氧合酶-2(COX-2)、多腺苷二磷酸核糖聚合酶10(PARP10)表达与临床病理特征及预后的关系。方法选取2020年1月至2021年6月南京医科大学第一附属医院收治的GEP-NENs患者122例,采用免疫组化检测GEP-NENs组织及对应瘤旁组织COX-2、PARP10表达。分析GEP-NENs组织中COX-2、PARP10表达与临床病理特征的关系,通过Kaplan-Meier法绘制不同COX-2、PARP10蛋白表达的GEP-NENs患者3年生存曲线;以GEP-NENs患者预后作为因变量,采用Cox回归分析影响患者预后的影响因素。结果与瘤旁组织比较,GEP-NENs组织中COX-2、PARP10阳性表达率升高(P<0.05)。COX-2、PARP10蛋白表达在不同肿瘤直径、TNM分期、病理分级、淋巴结转移和远处转移的患者中比较,差异有统计学意义(P<0.05),而在不同性别、年龄,以及不同位置肿瘤的患者中比较差异无统计学意义(P>0.05)。3年的随访期结束,患者失访3例,3年总生存率为78.15%(93/119)。由生存曲线可见,COX-2、PARP10蛋白阳性表达患者的3年的总生存率[69.88%(58/83)、69.62%(55/79)]高于COX-2、PARP10蛋白阴性表达患者[97.22%(35/36)、95.00%(38/40)](P<0.05)。多因素Cox回归分析结果显示,调整混杂因素(肿瘤大小、TNM分期、病理分级、淋巴结转移、远处转移)后,COX-2、PARP10蛋白阳性表达是GEP-NENs患者死亡的独立危险因素(P<0.05)。结论GEP-NENs组织中COX-2、PARP10高表达,与肿瘤大小、TNM分期、病理分级、淋巴结转移、远处转移及预后不良密切相关。Objective To investigate the relationship between the expression of cyclooxygenase-2(COX-2)and poly(ADP-ribose)polymerases(PARP)10(PARP10)in gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)tissues and their clinicopathological characteristics and prognosis.Methods A total of 122 patients with GEP-NENs treated at the First Affiliated Hospital of Nanjing Medical University from January 2020 to June 2021 were included.Immunohistochemistry was used to detect COX-2 and PARP10 expression in GEP-NENs tissues and corresponding adjacent non-tumor tissues.The relationship between COX-2 and PARP10 expression and clinicopathological features was analyzed.Kaplan-Meier survival curves were constructed for 3-year survival based on COX-2 and PARP10 expression levels.A Cox regression model was used to analyze prognostic factors affecting GEP-NENs patient outcomes,using prognosis as the dependent variable.Results The positive expression rates of COX-2 and PARP10 in GEP-NENs tissues were significantly higher than in adjacent non-tumor tissues(P<0.05).COX-2 and PARP10 expression levels varied significantly with tumor size,TNM stage,pathological grade,lymph node metastasis,and distant metastasis(P<0.05)but not with gender,age,or tumor location(P>0.05).During a 3-year follow-up,3 patients were lost to follow-up,and the overall 3-year survival rate was 78.15%(93/119).Patients with positive expression of COX-2 and PARP10 had lower 3-year survival rates[69.88%(58/83)and 69.62%(55/79),respectively]compared to patients with negative expression[97.22%(35/36)and 95.00%(38/40),respectively](P<0.05).Multivariate Cox regression analysis showed that,after adjusting for confounders(tumor size,TNM stage,pathological grade,lymph node metastasis,and distant metastasis),positive expression of COX-2 and PARP10 were independent risk factors for mortality in GEP-NENs patients(P<0.05).Conclusion Elevated expression of COX-2 and PARP10 in GEP-NENs tissues is closely associated with tumor size,TNM stage,pathological grade,lymph node metastasis,dis

关 键 词：胃肠胰神经内分泌肿瘤 环氧合酶-2 多腺苷二磷酸核糖聚合酶10 临床病理特征 预后 

分 类 号：R735[医药卫生—肿瘤]