血清CXCL16、CXCR3水平与胃癌癌前病变和胃癌的关系及诊断能效研究  

Study on the Relationship and Diagnostic Efficacy of Serum CXCL16 and CXCR3 Levels with Precancerous Lesions of Gastric Cancer and Gastric Cancer

作　　者：邵亚洲 SHAO Yazhou(Xifeng District Maternal and Child Health Hospital,Qingyang,Gansu 745000,China)

机构地区：[1]甘肃省庆阳市西峰区妇幼保健院,甘肃庆阳745000

出　　处：《转化医学杂志》2024年第9期1439-1443,1459,共6页Translational Medicine Journal

摘　　要：目的探讨血清C-X-C基序趋化因子配体16(CXCL16)、C-X-C基序趋化因子受体3(CXCR3)水平与胃癌癌前病变(PLGC)和胃癌(GC)的关系及诊断能效。方法选取2022年1月至2024年6月甘肃省庆阳市西峰区妇幼保健院收治的GC患者120例(GC组),按照1:1选取同期收治的PLGC患者120例(PLGC组)和健康体检志愿者120例(对照组)。采用酶联免疫吸附法检测血清CXCL16、CXCR3水平。以胃部病变为因变量,多元有条件无序Logistic回归分析血清CXCL16、CXCR3水平与PLGC和GC的关系,受试者工作特征(ROC)曲线分析血清CXCL16、CXCR3水平对PLGC和GC的诊断能效。结果GC组血清CXCL16、CXCR3水平高于PLGC组、对照组,PLGC组血清CXCL16、CXCR3水平高于对照组(P<0.05)。调整幽门螺杆菌、肿瘤家族史、胃泌素17、胃蛋白酶原Ⅰ/胃蛋白酶原Ⅱ、癌胚抗原、糖类抗原199、糖类抗原724、糖类抗原125后,CXCL16高、CXCR3高为PLGC和GC的独立危险因素(P<0.05)。血清CXCL16、CXCR3水平联合诊断PLGC的曲线下面积(AUC)为0.913,大于血清CXCL16、CXCR3水平单独诊断的0.845、0.836(P<0.05);血清CXCL16、CXCR3水平联合诊断GC的AUC为0.944,大于血清CXCL16、CXCR3水平单独诊断的0.882、0.879(P<0.05)。结论血清CXCL16、CXCR3水平升高与PLGC和GC发生密切相关,血清CXCL16、CXCR3水平联合对PLGC和GC的诊断能效较高。Objective To investigate the relationship and diagnostic efficacy of serum C-X-C motif chemokine ligand 16(CXCL16)and C-X-C motif chemokine receptor 3(CXCR3)levels in precancerous lesion of gastric cancer(PLGC)and gastric cancer(GC).Methods A total of 120 GC patients(GC group)admitted to our hospital from January 2022 to June 2024 were included.Additionally,120 PLGC patients(PLGC group)and 120 healthy volunteers(control group)matched 1:1 were selected.Serum CXCL16 and CXCR3 levels were measured using enzyme-linked immunosorbent assay.Multivariate conditional unordered logistic regression analysis was performed to explore the relationship between serum CXCL16 and CXCR3 levels with PLGC and GC,with gastric lesions as the dependent variable.Receiver operating characteristic(ROC)curves were used to evaluate the diagnostic efficacy of serum CXCL16 and CXCR3 levels for PLGC and GC.Results Serum CXCL16 and CXCR3 levels were significantly higher in the GC group compared to the PLGC and control groups,and higher in the PLGC group compared to the control group(P<0.05).After adjusting for Helicobacter pylori infection,family history of cancer,gastrin-17,pepsinogen I/pepsinogen II,carcinoembryonic antigen,carbohydrate antigen 199,carbohydrate antigen 724,and carbohydrate antigen 125,elevated CXCL16 and CXCR3 levels were identified as independent risk factors for PLGC and GC(P<0.05).The area under the curve(AUC)for the combined diagnosis of PLGC using serum CXCL16 and CXCR3 levels was 0.913,which was higher than the AUCs for CXCL16(0.845)or CXCR3(0.836)alone(P<0.05).Similarly,the combined diagnostic AUC for GC was 0.944,exceeding those of CXCL16(0.882)or CXCR3(0.879)alone(P<0.05).Conclusion Elevated serum CXCL16 and CXCR3 levels are closely associated with the development of PLGC and GC,and their combination demonstrates high diagnostic efficacy for both conditions.

关 键 词：胃癌 胃癌癌前病变 C-X-C基序趋化因子配体16 C-X-C基序趋化因子受体3 诊断能效 

分 类 号：R735[医药卫生—肿瘤]