癌胚抗原显著升高肺癌患者临床病理特征及预后分析  

Clinicopathologic features and prognosis of lung cancer patients with significantly elevated carcinoembryonic antigen levels

作　　者：刘英超[1] 李震 田佳 LIU Yingchao;LI Zhen;TIAN Jia(Clinical Laboratory,the Second People's Hospital of Liaocheng,Liaocheng 252600,China)

机构地区：[1]聊城市第二人民医院检验科,252600 [2]聊城市第二人民医院病理科,252600

出　　处：《浙江医学》2025年第2期184-187,共4页Zhejiang Medical Journal

基　　金：山东省医药卫生科技发展计划项目(2019WS105)。

摘　　要：目的分析癌胚抗原(CEA)显著升高(>50μg/L)肺癌患者临床病理特征及预后,提高临床对此类患者的认识。方法回顾性选取2019年1月至2020年12月聊城市第二人民医院收治的CEA显著升高肺癌患者65例作为观察组;另随机选取同期本院CEA异常(5~50μg/L)肺癌患者70例作为对照组。分析并比较两组患者临床病理特征差异;随访3年,绘制KaplanMeier生存曲线,分析并比较两组患者3年总生存率和累积生存率;采用多因素Cox回归分析影响患者预后的独立危险因素。结果两组患者性别、年龄、吸烟史等一般临床病理特征比较差异均无统计学意义(均P>0.05);与对照组相比,观察组患者病理类型为鳞癌、肿瘤直径>3 cm、发生淋巴结转移、肿瘤-淋巴结-远处转移(TNM)分期Ⅲ+Ⅳ期患者比例显著升高,可采用手术方式治疗患者比例显著降低,差异均有统计学意义(均P<0.05);随访结果显示观察组患者3年总生存率为21.5%,显著低于对照组的47.1%(P<0.05)。Kaplan-Meier生存曲线显示,观察组患者累积生存率显著低于对照组(P<0.01)。多因素Cox回归分析结果显示,CEA显著升高、淋巴结转移、TNM分期Ⅲ+Ⅳ期是影响肺癌患者预后的独立危险因素(均P<0.05)。结论CEA显著升高的肺癌患者临床病理特征较为显著,预后较差;CEA水平对预测肺癌患者预后具有重要意义。Objective To analyze the clinical and pathological features and prognosis of lung cancer patients with elevated carcinoembryonic antigen(CEA).Methods Sixty five lung cancer patients with markedly elevated CEA levels(>50μg/L)admitted in the Second People's Hospital of Liaocheng from January 2019 to December 2020 were enrolled(study group),and 70 lung cancer patients with moderately elevated CEA levels(5-50μg/L)were randomly selected as the control group.The clinical and pathological features were compared between the two groups.The patients were followed up for 3 years,and Kaplan-Meier survival curves were utilized to evaluate the three-year overall survival rate of both groups.The multivariate Cox regression model was applied to analyze the influencing factors of patient prognosis.Results There were no significant differences in gender,age,and smoking history between the two groups(all P>0.05).The study group exhibited a significantly higher proportion of squamous cell carcinoma,tumor size>3 cm,lymph node involvement,and TNM stageⅢ+Ⅳ,and less patients suitable for surgical intervention(all P<0.05).The three-year overall survival rate in the study group was significantly lower than that in the control group(21.5%vs.47.1%,P<0.05).The multivariate Cox regression analysis identified significantly elevated CEA,lymph node metastasis,and TNM stageⅢ+Ⅳas independent prognostic factors for lung cancer patients(all P<0.05).Conclusion Lung cancer patients with significantly elevated CEA levels present less favorable clinical and pathological features and a worse prognosis,indicating that the CEA level is a useful predictor of the prognosis in lung cancer patients.

关 键 词：癌胚抗原 肺癌 临床病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]