造血干细胞移植患者环境保护策略的变迁及思考  

Protective environment strategies for hematopoietic stem cell transplantation:progress and prospects

作　　者：周晓瑜[1] 章建丽[1] 许丽炜[1] 金爱云[1] ZHOU Xiaoyu;ZHANG Jianli;XU Liwei;JIN Aiyun(Nursing Department,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院护理部,浙江杭州310003

出　　处：《浙江大学学报(医学版)》2024年第6期796-803,共8页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江大学医学院附属第一医院护理学科建设专项基金(2022ZYHL047,2023ZYHL050)。

摘　　要：近年来,随着造血干细胞移植技术不断进步、预处理强度降低、患者骨髓抑制时间缩短、感染风险下降,以及整个移植过程中全环境保护导致医患生理、心理问题凸显,造血干细胞移植术后患者的环境保护策略受到重新审视。基于化疗患者中性粒细胞缺乏期间实施全环境保护与否不存在结局差异,人们对造血干细胞移植患者的全环境保护利弊进行权衡和反思后,逐步尝试打破造血干细胞移植患者的全环境保护,对环境保护改良策略进行摸索及改进。从最初的高效过滤装置代替层流设备,到开展移植后的居家护理工作,近二十年间造血干细胞移植患者的环境保护策略发展速度较快。本文回顾了造血干细胞移植患者环境保护策略的发展和变迁,提出对造血干细胞移植患者环境保护策略的进一步思考,为今后的环境保护改良提供参考。With the progress of hematopoietic stem cell transplantation technology,the reduction of pretreatment intensity,the shortening of bone marrow suppression time and the reduction of infection risk,especially the physical and psychological stress for doctors and patients caused by rigorous protection procedures,the protective environment strategies need improvement.It has been found that,regardless of whether total environment protection is implemented,there is no significant difference in the outcomes of chemotherapy patients with neutropenia.Therefore,the traditional protective environment strategies are being improved.The protective environment strategies for hematopoietic stem cell transplantation patients have developed rapidly in the past two decades,from the replacement of laminar flow equipment by high-efficiency filtration devices to the development of home care after transplantation.In this article,the progress in protective environment strategies for hematopoietic stem cell transplantation patients is reviewed and further reflect,providing reference for future improvement.

关 键 词：造血干细胞移植 环境保护 居家护理 策略 综述 

分 类 号：R733[医药卫生—肿瘤]