基于R语言数据挖掘中医药治疗重症急性胰腺炎的用药规律  

The medication rule of Chinese medicines in the treatment of severe acute pancreatitis based on R language data mining

作　　者：李卫芬 许飚 朱桂松[1] 邹子萌 孙妍 刘然 LI Weifen

机构地区：[1]南京中医药大学附属南京市中医院,江苏南京210022

出　　处：《中医临床研究》2024年第34期23-29,共7页Clinical Journal Of Chinese Medicine

基　　金：南京市医学科技发展项目(NO.YKK20165);南京市中医药青年人才培养项目(ZYQ20036)。

摘　　要：目的:基于R语言对数据库中重症急性胰腺炎的方药信息进行数据分析,探讨中医药治疗重症急性胰腺炎的用药规律。方法:计算机检索中国知网、中国生物医学文献数据库、维普、万方、PubMed共5个数据库,筛选出中药治疗重症急性胰腺炎相关文献。利用Excel软件汇总所有方药,运用R语言进行中药使用频数分析、关联规则分析和聚类分析等。结果:共筛选出方药245首,涉及中药171味,总用药频数为2 451次,使用频数≥21的中药共有26味,频数居前10位的依次为大黄、枳实、柴胡、厚朴、黄芩、芒硝、白芍、甘草、木香、延胡索,以清热药居多,其次为活血化瘀药、理气药、补虚药。所用中药药性偏寒、微寒、温,药味偏苦、辛、甘,主要归脾经、胃经、肝经。通过关联规则分析得到74条关联规则。关联规则分析和聚类分析分别形成以大黄、枳实、柴胡、黄芩、厚朴为基础的核心药物组合和以大承气汤为基础方的核心处方。结论:古代医家采用中药治疗重症急性胰腺炎以清热解毒、活血化瘀、化湿攻下为基本原则,酌情加入针对食滞、正虚等病机的中药。本研究挖掘出的核心药物组合和核心处方可更好地指导重症急性胰腺炎的临床治疗。Objective:The prescription information on severe acute pancreatitis in the database was analyzed by R language Oplatform to explore the medication rules of traditional Chinese medicine(TCM)in the treatment of severe acute pancreatitis.Methods:Five databases including CNKI,CBM,VIP,Wanfang,and PubMed were searched by computer to retrieve relevant literature on treating severe acute pancreatitis in TCM.Excel software was used to summarize all the included prescriptions,and R language was used to analyze the medication frequency,correlation rule and medicine clustering,etc..Results:A total of 245 prescriptions with 171 Chinese medicines were obtained after screening,the total frequency of medicines used was 2451 times,and there were 26 Chinese medicines used not less than 21 times.The top 10 most frequently used Chinese medicines were Dahuang(Radix et Rhizoma Rhei),Zhishi(Fructus Aurantii Immaturus),Chaihu(Radix Bupleuri),Houpo(Cortex Magnoliae Officinalis),Huangqin(Radix Scutellariae),Mangxiao(Natrii Sulfas),Baishao(Radix Paeoniae Alba),Gancao(Radix Glycyrrhizae),Muxiang(Radix Aucklandiae),Yanhusuo(Corydalis tuber)in order.Among the included medicines,heat-clearing medicines were most frequently used,followed by activating blood circulation to remove blood stasis medicines,regulating Qi(气)medicines,and tonifying medicines.The medicinal properties were mainly cold,slight cold,and warm;the medicinal flavors were mainly bitter,pungency,and sweet;the active ingredients were mainly absorbed by spleen meridian,stomach meridian,and liver meridian.The association rule analysis yielded 74 association rules.The core medicine combinations composed of Dahuang,Zhishi,Chaihu,Huangqin,and Houpo,and the core prescription with the Dachengqi decoction as the basic prescription were obtained by the association rule analysis and cluster analysis,respectively.Conclusion:Ancient medical practitioners used Chinese medicines to treat severe acute pancreatitis based on the basic principles of clearing heat and removing toxins,activating b

关 键 词：R语言 数据挖掘 重症急性胰腺炎 中医药 组方用药规律 

分 类 号：R576[医药卫生—消化系统]