基于“伏邪致痹”理论讨论“古丝绸之路”与白塞病发病的相关性  

Discussion on the correlation between the ancient Silk Road and the onset of Behcet’s disease based on the theory of latent pathogenic factors cause arthralgia syndrome

作　　者：林佳瑾 吴方真[2] 罗钰杰 赵宇杉 施倩 胡根莲 杨灵芝 赵钟文[2] LIN Jiajin

机构地区：[1]福建中医药大学,福建福州350003 [2]福建中医药大学附属第二人民医院,福建福州350003

出　　处：《中医临床研究》2024年第34期86-89,共4页Clinical Journal Of Chinese Medicine

基　　金：2023年福建省科技计划项目(2023Y0029):基于伏邪致痹理论探讨痛风饮维持缓解期痛风性关节炎患者尿酸稳定及改善内脏代谢的临床研究。

摘　　要：“伏邪致痹”是指邪气入侵机体之后潜伏于里,感时而发病。白塞病(Behcet’s Disease,BD)又称“古丝绸之路病”,主要的临床表现是口腔、生殖器、眼部等部位出现黏膜溃疡,又称口腔、生殖器、眼部三联征。现代研究表明,BD的易感性与机体携带的HLA-B51基因相关,此外环境中的病毒和细菌所引起的炎症反应也参与其中,炎性微环境具有促集、黏着等特性,与中医“伏邪”的特性相似。饮食偏嗜伤及脾胃,可引起气机升降失常,从而造成湿热内生,为“伏邪”提供致病条件。本研究基于“伏邪致痹”理论,从基因易感性、饮食因素、环境影响等方面探讨古代丝绸之路与BD的相关性。The general idea of“Latent pathogenic factors cause arthralgia syndrome”is that after invading the body,the pathogens lurks in the body,and attacks when the time is right.Behcet’s disease,also known as“ancient Silk Road disease”,is characterized by mucosal ulcers in the mouth,genitals,eyes and other parts,also known as“eye mouth genitals triad syndrome”.According to modern research,the susceptibility of Behcet’s disease is related to the HLA-B51 gene carried by the body.In addition,the inflammatory response caused by viruses and bacteria in the environment is also involved.The inflammatory microenvironment has the characteristics of collection and adhesion,which is similar to the characteristics of“hidden pathogen,in traditional Chinese medicine.Diet preference injury to the spleen and stomach can cause abnormal rise and fall of Qi(气)circulation,resulting in endogenous damp heat,providing pathogenic conditions for“hidden pathogen”.Therefore,based on the theory of“Latent pathogenic factors cause arthralgia syndrome”,this paper discusses the correlation between the ancient Silk Road and Behcet’s disease from the aspects of genetic susceptibility,dietary factors and environmental impact.

关 键 词：白塞病 古丝绸之路 基因 饮食 环境 

分 类 号：R364.16[医药卫生—病理学]