呼吸道菌群在非小细胞肺癌肿瘤免疫微环境和免疫治疗中的作用  

Role of respiratory microbiota in the tumor immune microenvironment and immunotherapy of non-small cell lung cancer

作　　者：董文博 余浩洋 朱逸凡 张指舰 李文扬[4] 孔德磊[4] DONG Wenbo;YU Haoyang;ZHU Yifan;ZHANG Zhijian;LI Wenyang;KONG Deei(The First Clinical College,China Medical University,Shenyang 110122,China;The Second Clinical College,China Medical University,Shenyang 110122,China;The Forth Clinical College,China Medical University,Shenyang 110122,China;Department of Respiratory andCritical Care Medicine,The First Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学第一临床学院,沈阳110122 [2]中国医科大学第二临床学院,沈阳110122 [3]中国医科大学第四临床学院,沈阳110122 [4]中国医科大学附属第一医院呼吸与危重症医学科,沈阳110001

出　　处：《中国医科大学学报》2025年第1期82-86,共5页Journal of China Medical University

基　　金：国家自然科学基金(82370093);中华国际医学交流基金会呼吸疾病青年实用研究项目(Z-2017-24-2301)。

摘　　要：微生物群可以被人类免疫系统识别并引起特定的免疫反应,通过复杂的调控机制参与疾病的发生和发展。肿瘤微环境涉及到肿瘤周围细胞外基质、免疫细胞、肿瘤相关的成纤维细胞和内皮细胞等,其中免疫细胞代表的肿瘤免疫微环境影响癌症的进展和治疗,而肿瘤免疫微环境与肿瘤微生物群密切相关。呼吸道菌群的表达与非小细胞肺癌的分型和分期有一定相关性。本文深入阐述了呼吸道菌群在肿瘤免疫微环境中对先天免疫细胞和特异性免疫细胞的作用机制,并探讨了其在非小细胞肺癌免疫治疗中的作用,以期为非小细胞肺癌的诊断和治疗提供潜在的生物标志物。Microbiota can be recognized by the human immune system,trigger specific immune responses,and play a significant role in the onset and progression of diseases through intricate regulatory mechanisms.The tumor microenvironment comprises the peritumoral extracellular matrix,immune cells,tumor-associated fibroblasts,and endothelial cells,among others.In this context,the tumor immune microenvironment,characterized by immune cells,significantly influences cancer progression and treatment.Notably,the tumor immune microenvironment is closely associated with the tumor microbiota.The presence of respiratory microbiota is correlated with the typing and staging of non-small cell lung cancer.This study investigated the mechanisms by which respiratory microbiota affect innate and adaptive immune cells within the tumor immune microenvironment and explored the role of respiratory microbiota in the immunotherapy of non-small cell lung cancer.The aim was to identify potential biomarkers that could enhance the diagnosis and treatment of non-small cell lung cancer.

关 键 词：非小细胞肺癌 呼吸道菌群 肿瘤免疫微环境 先天免疫 特异性免疫 抗肿瘤免疫治疗 

分 类 号：R734.2[医药卫生—肿瘤]