高压氧疗法治疗瘘管型克罗恩病的作用机制、有效性及安全性研究进展  

Research progress on mechanism,efficacy and safety of hyperbaric oxygen therapy in treatment of fistulizing Crohn's disease

作　　者：吴慧慧 葛媛媛 丁康[1] 刘翔宇 张苏闽[1] WU Huihui;GE Yuanyuan;DING Kang;LIU Xiangyu;ZHANG Sumin(Department of Colorectal Surgery,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China)

机构地区：[1]南京中医药大学附属南京中医院结直肠外科,江苏南京210022

出　　处：《山东医药》2025年第1期123-128,共6页Shandong Medical Journal

基　　金：国家自然科学基金项目(82200579);国家中医临床研究基地(江苏省中医院)开放课题项目(JD2023SZX10);江苏省研究生科研与实践创新计划项目(SJCX24_1100)。

摘　　要：克罗恩病是一种原因不明、反复发作的消化道慢性炎症性疾病,瘘管型克罗恩病作为克罗恩病的严重表型之一,极难治疗,缓解率低,目前已知的少数有效疗法在实现瘘管型克罗恩病持续缓解方面仍然效果欠佳。高压氧疗法(HBOT)通过在高于一个大气压的环境下让患者吸入100%氧气以增加组织氧水平并调节炎症,正逐渐被视为治疗瘘管型克罗恩病的一种有潜力的治疗选择。HBOT治疗瘘管型克罗恩病瘘管愈合率良好,且绝大多数患者均对治疗具有良好的耐受性,在瘘管型克罗恩病的治疗中具有良好的应用前景。对HBOT应用于瘘管型克罗恩病治疗中的作用机制、有效性及安全性进行探讨,可为临床提供更多的治疗选择并优化现有治疗方案。Crohn´s disease(CD),characterized by its elusive etiology,is a recalcitrant chronic inflammatory disease affecting the digestive tract.Fistulizing Crohn´s disease(CD),one of the severe phenotypes of CD,is extremely difficult to treat,with a low remission rate.Currently,the few known effective therapies still have limited efficacy in achieving sustained remission of fistulizing CD.Hyperbaric oxygen therapy(HBOT),which enables patients to inhale 100%oxygen in an environment with a pressure higher than the atmospheric pressure to increase tissue oxygen levels and regulate inflammation,is gradually being regarded as a potential treatment option for fistulizing CD.HBOT demonstrates a favorable fistula healing rate in the treatment of fistulizing CD,and most of the patients show good tolerance to the treatment.Thus,it holds promising application prospects in the treatment of fistulizing CD.Exploring the mechanism of action,efficacy,and safety of HBOT in the treatment of fistulizing CD can provide more treatment options for clinical practice and optimize existing treatment regimens.

关 键 词：高压氧疗法 克罗恩病 瘘管 有效性 安全性 

分 类 号：R574[医药卫生—消化系统]