Growing burden of inflammatory bowel disease in China:Findings from the Global Burden of Disease Study 2021 and predictions to 2035  

作　　者：Ziqing Yu Gechong Ruan Xiaoyin Bai Yinghao Sun Hong Yang Jiaming Qian 

机构地区：[1]Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China.

出　　处：《Chinese Medical Journal》2024年第23期2851-2859,共9页中华医学杂志(英文版)

基　　金：Capital Health Research and Development of Special Foundation(No.2022-2-4014);National Key Clinical Specialty Construction Project(No.ZK108000);National High-Level Hospital Clinical Research Funding(Nos.2022-PUMCH-B-022,2022-PUMCH-C-018,2022-PUMCH-A-074,and 2022-PUMCH-A-179);National Natural Science Foundation of China(No.81970495);CAMS Innovation Fund for Medical Sciences(No.2022-I2M-C&T-B-011);National Key R&D Program of China(No.2023YFC2507300,2023YFC2507302);State Key Laboratory Special Fund(No.2060204);Undergraduate Training Program on Innovation and Entrepreneurship(No.2024dcxm091)。

摘　　要：Background:Inflammatory bowel disease(IBD)imposes a significant economic and social burden in China.We aim to assess the epidemiological trends of IBD in China,and to predict the burden in the near future.Methods:The incidence,mortality,prevalence,and disability-adjusted life year(DALYs)of IBD from 1990 to 2021 were obtained from Global Burden of Disease Study 2021.Estimated annual percentage change(EAPC),average annual percent change,total percent change,and age-period-cohort model were used to access trends.Bayesian age–period–cohort model was utilized to predict the risk of incidence and mortality.Results:In 2021,IBD affected 168,077 people in China,with 24,941 new cases and 5640 deaths.The age-standardized rate(ASR)of incidence and death was 1.4 and 0.3,respectively.The incidence and prevalence in China were lower than the global and high socio-demographic index(SDI)regions,but the ASR of incidence and prevalence(EAPC:2.93 and 2.54,respectively)had rapidly increased from 1990 to 2021.The ASR of death and DALYs had significantly decreased(EAPC:−3.05 and−2.93,respectively).Middle-aged and elderly populations faced a severe burden of incidence and prevalence,while the elderly population faced a severe mortality burden.It is projected that by 2035,the ASR of incidence will continue to rise,whereas the death rate will continue to decline.Conclusions:The burden of IBD in China is serious and increasingly severe.Establishing a comprehensive disease management system in China will help better control the medical burden of IBD.

关 键 词：Inflammatory bowel disease INCIDENCE PREVALENCE Global Burden of Disease Disease burden China 

分 类 号：R57[医药卫生—消化系统]