Tapinarof inhibits psoriatic inflammation through inducing tolerogenic dendritic cells and Foxp3^(+) Tregs  

作　　者：Yan Zhao Chenyu Wu Lin Cai Zhanglei Mu Xiaoyang Liu Wenge Zhang Jianzhong Zhang 

机构地区：[1]Department of Dermatology,Peking University People’s Hospital,Beijing 100044,China

出　　处：《Chinese Medical Journal》2024年第23期2877-2879,共3页中华医学杂志(英文版)

基　　金：supported by a grant from the National Natural Science Foundation of China(No.81972933).

摘　　要：To the Editor:Tapinarof is an aryl hydrocarbon receptor(AhR)ligand derived from metabolites of Photorhabdus luminescens.[1]It has been shown that 1%tapinarof cream had high efficacy on psoriasis,[2]and has been approved for the treatment of psoriasis in China and in the United States.The“interleukin(IL)-23/IL-17-producing T helper(Th17)inflammation axis”plays a predominant role in the pathogenesis of psoriasis.Tapinarof also suppresses the expression of IL-17 and inhibits oxidative stress.[3]Here,we studied the role of tapinarof on dendritic cells(DCs)activation and on differentiation of Th17 and Treg in human and mouse.We also studied the effect of tapinarof in imiquimod(IMQ)-induced mice psoriasis model.

关 键 词：FOXP3 INFLAMMATION TH17 

分 类 号：R75[医药卫生—皮肤病学与性病学]