H3 G34突变型弥漫性半球胶质瘤的影像学分析  

The Imaging Analysis of Diffuse Hemispheric Gliomas H3 G34-mutant

作　　者：庞炳昕 袁梦媛 李杰 王军梅[4] 邹婉婧 孙胜军[3,5] PANG Bingxin;YUAN Mengyuan;LI Jie(Department of CT/MR,Xingtai People’s Hospital,Xingtai,Hebei Province 054001,P.R.China)

机构地区：[1]邢台市人民医院CT/MR科,054001 [2]邢台市人民医院神经内四科,054001 [3]北京市神经外科研究所放射科,100070 [4]北京市神经外科研究所神经病理室,100070 [5]首都医科大学附属北京天坛医院放射科,北京100070

出　　处：《临床放射学杂志》2025年第2期207-210,共4页Journal of Clinical Radiology

摘　　要：目的观察并分析H3 G34突变型弥漫性半球胶质瘤(H3 G34-DHG)的CT和MRI表现。方法回顾性分析33例经活检或手术病理证实为H3 G34-DHG的临床及影像学资料。结果33例均位于大脑半球,31例为单发,其中12例呈团块状,4例呈脑回样,15例呈片状;2例为多发。21例边界清晰,6例跨中线生长。9例伴出血,17例伴囊变坏死。28例行CT检查,实性部分为等或略高密度,6例钙化。MRI表现29例扩散加权成像(DWI)扩散受限,14例伴异常血管,4例内部见残存皮层下U型纤维。T 1WI增强扫描12例无强化,8例轻度强化,13例结节状或不规则明显强化;9例伴邻近柔脑膜强化,1例伴脑干表面强化。10例存在瘤周水肿。结论H3 G34-DHG影像有一定共性特征:多单发,常位于大脑半球表浅区,CT等/稍高密度,DWI扩散受限,囊变坏死多见,可伴出血,可伴异常血管,强化方式多样,可伴邻近柔脑膜强化,部分伴瘤周水肿。Objective To observe and analyse the imaging features of diffuse hemispheric gliomas,H3 G34-mutant.Methods The clinical data and imaging findings of 33 cases of H3 G34-mutant diffuse hemispheric gliomas with confirmed by pathology were analyzed retrospectively.Results 33 cases were located in the cerebral hemisphere,31 cases showed single lesion,2 cases showed multiple lesions.The single lesion showed the form of mass(12 cases),gyrus(4 cases)and patch(15 cases).21 cases showed clear boundary,and 6 cases grew across the midline.9 cases showed hemorrhage,and 17 cases showed cystic degeneration or necrosis.28 cases underwent CT scans,all the solid parts showed equal or slightly higher density,and 6 cases showed calcification.29 cases showed restricted diffusion in DWI.14 cases showed abnormal blood vessels,and 4 cases showed residual subcortical U-shaped fibers.Contrast enhancement patterns:12 cases showed no enhancement,8 cases showed mild enhancement and 13 cases showed obvious enhancement.9 cases showed the adjacent leptomeningeal enhancement and 1 case showed the surface of the brainstem enhancement.10 cases showed peritumoral edema.Conclusion The typical H3 G34-mutant diffuse hemispheric gliomas is a single lesion and tends to locate in the superficial area of the cerebral hemisphere,with high density on CT scans and restricted diffusion on DWI.It is often accompanied by cystic degeneration or necrosis and may shows hemorrhage or abnormal blood vessels.The enhancement is various.Adjacent leptomeningeal enhancement and peritumoral edema may be occurred.

关 键 词：弥漫性半球胶质瘤 H3 G34突变型 磁共振成像 体层摄影术 X线计算机 

分 类 号：R73[医药卫生—肿瘤]