中医药调节HPA-HPT-HPG轴治疗抑郁症的研究进展  

Research advances in regulation of the hypothalamic-pituitary-adrenal/hypothalamic-pituitary-thyroid/hypothalamic-pituitary-gonadal axes in the treatment of depression by traditional Chinese medicine

作　　者：李超 李继安 田朝阳 蒲菁菁 李嘉钰 韩茹杰 张碧溦 王萌 LI Chao;LI Jian;TIAN Zhaoyang;PU Jingjing;LI Jiayu;HAN Rujie;ZHANG Biwei;WANG Meng(College of Traditional Chinese Medicine,North China University of Science and Technology,Tangshan 063210,China;Hebei Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for the Prevention and Treatment of Diabetes and Its Complications,Tangshan 063210)

机构地区：[1]华北理工大学中医学院,河北唐山063210 [2]河北省中西医结合防治糖尿病及其并发症重点实验室,河北唐山063210

出　　处：《中国比较医学杂志》2024年第12期102-110,共9页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82205066);河北省自然科学基金中医药联合基金重点项目(H2023209058);河北省创新能力提升计划项目(19392507D)。

摘　　要：抑郁症的发病机制复杂、治疗手段局限,阐明其发病机制和开发新的治疗药物具有重要意义。目前,激素和激素操纵化合物已被用于治疗抑郁症,其治疗作用不仅归因于外围内分泌系统的调节,还归因于激素对非内分泌脑回路的中枢神经系统的影响。HPA-HPT-HPG轴与抑郁症的发病机制关系密切。中医药治疗抑郁症的作用机制广泛,对3条轴的调节是其重要的作用机制之一。本文基于激素和激素操纵子化合物参与抑郁症的病理学和治疗的新证据,对当前中医药治疗抑郁症的相关机制进行了归纳,以期为中医药治疗抑郁症基础研究提供思路和借鉴。Thepathogenesisof depression iscomplex and treatment method arecurrently limited,and it is therefore important to clarify its pathogenesis and develop new therapeutic drugs.Hormones and hormone-modifying compounds have been used to treat depression,and their therapeutic effects are attributed to regulation of the peripheral endocrine system and their effects on non-endocrine circuits in the central nervous system.The hypothalamic-pituitary-adrenal(HPA)/hypothalamic-pituitary-thyroid(HPT)/hypothalamic-pituitary-gonadal(HPG)axes are closely related to the pathogenesis of depression.The mechanism of action of traditional Chinese medicines in the treatment of depression is extensive,and the three axes are regulated in a variety of ways.Based on new evidence of hormones and hormone operon compounds involved in the pathology and treatment of depression,this review summarizes the relevant mechanisms of current traditional Chinese medicine in the treatment of depression,to provide new ideas and references for traditional Chinese medicine research.

关 键 词：中医药 HPA HPT HPG 抑郁症 研究进展 

分 类 号：R-33[医药卫生]