DNA甲基转移酶在缺氧/缺血预处理DNA中的神经保护作用研究  

Role of DNA methyltransferases in neuroprotection during hypoxia/ischemia preconditioning

作　　者：李瑞学 谢雅彬 邵国[1,2] LI Ruixue;XIE Yabin;SHAO Guo(Key Laboratory of Hypoxia Translational Medicine,Baotou Medical College,Baotou 014040,China;Center for Translational Medicine,the Third People’s Hospital of Longgang District,Shenzhen 518112)

机构地区：[1]包头医学院低氧转化医学重点实验室,内蒙古包头014040 [2]龙岗区第三人民医院转化医学中心,广东深圳518112

出　　处：《中国比较医学杂志》2024年第12期111-116,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82060337);深圳市龙岗区医疗卫生科技计划项目(LGKCYLWS2021000033,LGKCYLWS2023025);深圳市科技计划项目基础研究面上项目(JCYJ20220531092412028,JCYJ20230807121306012);内蒙古自治区自然科学基金项目(2021LHMS08022);包头医学院博士科研启动基金项目(BSJJ201804)。

摘　　要：低氧/缺血预适应(hypoxic/ischemic preconditioning,H/IPC)可诱导内源性保护机制使神经细胞增加对低氧/缺血的耐受,这种保护机制是细胞在生死抉择时基因表达的变化。DNA甲基化作为基因表达调控的重要机制,在低氧/缺血耐受中发挥着至关重要的作用。DNA甲基化转移酶(DNA methyltransferases,DNMTs)通过调控DNA甲基化水平影响基因表达,从而对神经保护产生重要作用。因此,DNMTs在低氧/缺血预适应诱导的神经保护中具有重要功能。本文对DNMTs在此过程中的作用进行了综述,为以DNMTs为靶点的神经保护研究提供了一定思路。Hypoxic/ischemic preconditioning(H/IPC)can induce endogenous protective mechanisms that increase the tolerance of nerve cells to hypoxia/ischemia.This protective mechanism involves changes in gene expression during the critical decisionmaking period between cell survival and death.DNA methylation,as a crucial mechanism for gene expression regulation,plays an essential role in hypoxia/ischemia tolerance.DNA methyltransferases(DNMTs)contribute to neuroprotection by influencing gene expression via regulating DNA methylation levels.DNMTs thus have important functions in the neuroprotection induced by hypoxic/ischemic preconditioning.This paper reviews the role of DNMTs in this process,providing insights into neuroprotection targeting DNMTs.

关 键 词：神经保护 低氧/缺血预适应 DNA甲基化转移酶 

分 类 号：R-33[医药卫生]