外泌体miRNAs在甲基苯丙胺诱导的神经毒性及戒断药物研发中的研究进展  

Research progress on the role of exosomal microRNAs in methamphetamineinduced neurotoxicity and drug development

作　　者：周莹 孙威 杨根梦 董文娟 戴睿 洪仕君 李利华 ZHOU Ying;SUN Wei;YANG Genmeng;DONG Wenjuan;DAI Rui;HONG Shijun;LI Lihua(Electron Microscopy Laboratory,Research and Experimental Center,Kunming Medical University,Kunming 650500,China;School of Forensic Medicine,NHC Key Laboratory of Drug Addiction Medicine,Kunming Medical University,Kunming 650500;Department of Human Anatomy,School of Basic Medical Sciences,Kunming Medical University,Kunming 650500)

机构地区：[1]昆明医科大学科研实验中心电子显微镜实验室,昆明650500 [2]昆明医科大学法医学院,国家卫生健康委员会毒品依赖和戒治重点实验室,昆明650500 [3]昆明医科大学基础医学院人体解剖学实验室,昆明650500

出　　处：《中国比较医学杂志》2024年第12期117-126,共10页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82260336,82371898)。

摘　　要：甲基苯丙胺(methamphetamine,METN)作为一种被广泛滥用的新型毒品,具有极强的中枢兴奋作用,其中枢兴奋作用途径涉及一系列中枢高级功能,包括与滥用相关的奖赏与动机、学习与记忆、决策与执行等。METH不仅会引发机体神经毒性,长期使用会造成成瘾者认知功能障碍、人格缺失并引发严重的社会暴力行为。外泌体作为细胞间通信的新载体,参与毒品成瘾的发生和发展。外泌体miRNAs不仅是METH成瘾的重要生物标志物,还参与METH神经毒性反应的各个环节,与其相关的药物作用机制研究可以为METH滥用和依赖的临床诊断和治疗提供新思路。Methamphetamine(METH)is a new type of abused drug with a strong central stimulant effect.Its excitatory pathway involves a series of central higher-level functions,including drug-related rewards and motivation,learning and memory,decision-making,and execution.METH not only causes neurotoxicity,but its long-term use may also cause cognitive dysfunction,loss of personality,and may lead to serious social violence in addicts.Exosomes,as a novel cell-to-cell carrier,are involved in the occurrence and development of drug addiction,and exosome microRNAs are important biomarkers for METH addiction and are also involved in various aspects of METH-induced neurotoxicity.Eoxosmes may thus be useful therapeutic carriers providing a new approach for the diagnosis and treatment of METH abuse.

关 键 词：甲基苯丙胺 外泌体miRNAs 神经毒性 药物治疗 

分 类 号：R-33[医药卫生]