核因子E2相关因子2在脊髓损伤后氧化应激中的研究进展  

Research progress in nuclear factor E2-related factor 2 in oxidative stress after spinal cord injury

作　　者：席回林 吴佳俊 王青燕 白心悦 何盟泽 杨彦玲[1] XI Huilin;WU Jiajun;WANG Qingyan;BAI Xinyue;HE Mengze;YANG Yanling(Medical School of Yan’an University,Yan’an 716000,China)

机构地区：[1]延安大学医学院,延安716000

出　　处：《中国比较医学杂志》2024年第12期136-142,共7页Chinese Journal of Comparative Medicine

基　　金：陕西省重点研发计划项目(2024SF-YBXM-037);榆林市第一医院横向课题(YAU202301791);延安大学研究生教育创新计划项目(YCX2024103,YCX2024108)。

摘　　要：脊髓损伤(spinal cord injury,SCI)是一种高发病率、高致残率和高死亡率的中枢神经系统疾病。SCI后出现一系列病理和生理变化,如氧化应激,会促进损伤部位微环境的进一步恶化,导致神经功能受损。核因子E2相关因子2(nuclear factor E2-related factor 2,Nrf2)是一种与氧化应激高度关联的因子,因此,靶向调控Nrf2缓解氧化应激可能是SCI的治疗方法之一。本文从SCI后氧化应激的发生和氧化应激与Nrf2的关系着手,论述Nrf2在SCI后氧化应激中的应用,并且总结了靶向调控Nrf2的策略,如基因、非编码RNA和药物,希望为SCI的靶向治疗提供新的思路。Spinal cord injury(SCI)isacentral nervoussystemdiseasewith high morbidity,disability,and mortality.A series of pathological and physiological changes after SCI,including oxidative stress,can promote further deterioration of the microenvironment at the injury site,resulting in impaired neurological function.Nuclear factor E2-related factor 2(Nrf2)is highly correlated with oxidative stress,suggesting that targeting the regulation of Nrf2 and alleviating oxidative stress may be an effective treatment for SCI.We consider the application of Nrf2 in post-SCI oxidative stress,based on the occurrence of oxidative stress after SCI and the relationship between oxidative stress and Nrf2.We also summarize the strategies for targeting and regulating Nrf2,including genes,non-coding RNAs,and drugs,with the aim of providing new ideas for targeted therapy of SCI.

关 键 词：NRF2 SCI 氧化应激 

分 类 号：R-33[医药卫生]