慢性失眠障碍患者血清炎症因子与过度觉醒、认知功能的相关性分析  

Correlation analysis of serum inflammatory factors with excessive awakening and cognitive function in patients with chronic insomnia disorder

作　　者：王硕 徐乔乔 程方 余锋[2] 席春华 WANG Shuo;XU Qiaoqiao;CHENG Fang;YU Feng;XI Chunhua(the Third Affiliated Hospital of Anhui Medical University/Hefei First People's Hospital,Hefei 230000;Anhui Provincial Hospital,Hefei 230000,China)

机构地区：[1]安徽医科大学第三附属医院/合肥市第一人民医院,安徽合肥230000 [2]安徽省立医院,安徽合肥230000

出　　处：《临床医学研究与实践》2025年第3期42-46,共5页Clinical Research and Practice

基　　金：2024年度安徽省中医药传承创新科研项目(No.2024CCCX230);2022年安徽省临床医学研究转化专项项目(No.202204295107020024);2023年度合肥市卫生健康应用医学科研项目(No.Hwk2023yb003);2022年度合肥市卫生健康应用医学研究项目(No.Hwk2022zd002)。

摘　　要：目的 分析慢性失眠障碍(CID)患者血清炎症因子与过度觉醒、认知功能的相关性。方法 选取2022年10月至2023年10月安徽医科大学第三附属医院诊治的39例CID患者为CID组,35名健康者作为健康组。比较两组研究对象的精神心理状态、睡眠质量、觉醒程度、认知功能及血清炎症因子水平;采用Pearson相关性分析探究炎症因子与过度觉醒、认知功能的相关性。结果 CID组的焦虑自评量表(SAS)、抑郁自评量表(SDS)、匹兹堡睡眠质量指数(PSQI)评分高于健康组(P<0.05)。CID组的过度觉醒量表(HAS)评分高于健康组,词汇流畅性测试(VFT)、数字广度-顺背(DS-F)、数字广度-倒背(DS-B)及符号-数字模式测验(SDMT)评分低于健康组(P<0.05)。CID组的白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、皮质醇水平高于健康组,白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、脑源性神经营养因子(BDNF)水平低于健康组(P<0.05)。Pearson相关性分析结果显示,在CID患者中,IL-1β水平与PSQI、HAS评分呈正相关,与VFT、DS-B、SDMT评分呈负相关(P<0.05);TNF-α水平与PSQI、HAS评分呈正相关,与SDMT评分呈负相关(P<0.05);皮质醇水平与PSQI、HAS评分呈正相关,与SDMT评分呈负相关(P<0.05);IL-10水平与HAS评分呈负相关,与DS-B评分呈正相关(P<0.05);BDNF水平与DS-B、SDMT评分呈正相关(P<0.05)。结论 CID患者的IL-1β、TNF-α、皮质醇水平升高,IL-4、IL-10、BDNF水平降低,且其与过度觉醒、认知功能相关。Objective To analyze the correlation analysis of serum inflammatory factors with excessive awakening and cognitive function in patients with chronic insomnia disorder(CID).Methods Thirty-nine patients with CID diagnosed and treated in the Third Affiliated Hospital of Anhui Medical University from October 2022 to October 2023 were selected as CID group,and 35 healthy people were selected as healthy group.The mental state,sleep quality,awakening degree,cognitive function and serum inflammatory factor level of the two groups were compared;Pearson correlation analysis was used to explore the correlation between inflammatory factors and excessive awakening and cognitive function.Results The scores of Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS)and Pittsburgh Sleep Quality Index(PSQI)in the CID group were higher than those in the healthy group(P<0.05).The score of Hyperarousal Scale(HAS)in the CID group was higher than that in the healthy group,and the scores of Verbal Fluency Test(VFT),Digit Span-Forward Task(DS-F),Digit Span-Backward Task(DS-B)and Symbol-Digit Modalities Test(SDMT)were lower than those in the healthy group(P<0.05).The levels of interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and cortisol in the CID group were higher than those in the healthy group,and the levels of interleukin-4(IL-4),interleukin-10(IL-10)and brain-derived neurotrophic factor(BDNF)were lower than those in the healthy group (P<0.05). Pearson correlation analysis results showed that in CID patients, IL-1β level was positively correlated with PSQI and HAS scores, and negatively correlated with VFT, DS-B and SDMT scores (P<0.05);the level of TNF-α was positively correlated with PSQI and HAS scores, and negatively correlated with SDMT score (P<0.05);cortisol level was positively correlated with PSQI and HAS scores, and negatively correlated with SDMT score (P<0.05);the level of IL-10 was negatively correlated with HAS score and positively correlated with DS-B score (P<0.05);the level of BDNF was positively co

关 键 词：慢性失眠障碍 炎症因子 过度觉醒 认知功能 

分 类 号：R749.1[医药卫生—神经病学与精神病学]