血清GPC-3、PHCA、GP73联合检测在原发性肝癌诊断中的价值及与肝纤维化的相关性分析  

Value of combined detection of serum GPC-3, PHCA, and GP73 in the diagnosis of primary liver cancer and its correlation with liver fibrosis

作　　者：李双雁 侯小莉 LI Shuangyan;HOU Xiaoli(Laboratory Department,Shaanxi Province Mianxian Hospital,Hanzhong 724200,China)

机构地区：[1]陕西省勉县医院检验科,陕西汉中724200

出　　处：《临床医学研究与实践》2025年第3期91-94,共4页Clinical Research and Practice

摘　　要：目的 探讨血清磷脂酰肌醇蛋白多糖-3(GPC-3)、人肝癌抗原(PHCA)、高尔基体蛋白73(GP73)联合检测在原发性肝癌诊断中的价值及与肝纤维化的相关性。方法 选取2022年3月至2023年5月我院收治的64例原发性肝癌患者作为原发性肝癌组,另选取同期收治的92例良性肝病患者作为良性肝病组。比较两组的GPC-3、PHCA、GP73及肝纤维化指标水平,比较GPC-3、PHCA、GP73单独及联合检测对原发性肝癌的诊断效能,并探讨血清GPC-3、PHCA、GP73与肝纤维化指标的相关性。结果 原发性肝癌组的血清GPC-3、PHCA、GP73水平明显高于良性肝病组,差异具有统计学意义(P<0.05)。原发性肝癌组的GPC-3、PHCA、GP73单独及联合检测阳性率均明显高于良性肝病组,差异具有统计学意义(P<0.05)。GPC-3、PHCA、GP73联合检测诊断原发性肝癌的灵敏度明显高于GPC-3、PHCA、GP73单独检测,差异具有统计学意义(P<0.05);GPC-3、PHCA、GP73联合检测诊断原发性肝癌的准确度明显高于GP73单独检测,差异具有统计学意义(P<0.05)。原发性肝癌组的血清Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层粘连蛋白(LN)水平明显高于良性肝病组,差异具有统计学意义(P<0.05)。Pearson相关性分析结果显示,原发性肝癌患者血清GPC-3、PHCA、GP73水平与血清Ⅳ-C、HA、PCⅢ、LN水平均呈正相关(P<0.05)。结论 GPC-3、PHCA、GP73在原发性肝癌患者血清中均呈高表达,三种指标联合检测对原发性肝癌具有较高的诊断效能,且血清GPC-3、PHCA、GP73水平与肝纤维化存在相关性。Objective To explore the value of combined detection of serum glypican-3(GPC-3),human hepatocellular carcinoma antigen(PHCA)and golgi protein 73(GP73)in the diagnosis of primary liver cancer and its correlation with liver fibrosis.Methods Sixty-four patients with primary liver cancer admitted in our hospital from March 2022 to May 2023 were selected as primary liver cancer group,and 92 patients with benign liver disease admitted in our hospital during the same period were selected as benign liver disease group.The levels of GPC-3,PHCA,GP73 and liver fibrosis indexes were compared between the two groups,the diagnostic efficacy of GPC-3,PHCA,GP73 alone and combined detection for primary liver cancer were compared,and the correlation between serum GPC-3,PHCA,GP73 and liver fibrosis indexes were discussed.Results The levels of serum GPC-3,PHCA and GP73 in the primary liver cancer group were significantly higher than those in the benign liver disease group,and the differences were statistically significant(P<0.05).The positive rates of GPC-3,PHCA,GP73 alone and combined detection in the primary liver cancer group were significantly higher than those in the benign liver disease group,and the differences were statistically significant(P<0.05).The sensitivity of combined detection of GPC-3,PHCA and GP73 in the diagnosis of primary liver cancer was significantly higher than that of GPC-3,PHCA and GP73 alone detection,and the differences was statistically significant(P<0.05);the accuracy of combined detection of GPC-3,PHCA and GP73 in the diagnosis of primary liver cancer was significantly higher than that of GP73 alone detection,and the difference was statistically significant(P<0.05).The serum levels of typeⅣcollagen(IV-C),hyaluronic acid (HA), procollagen typeⅢ (PCⅢ) and laminin (LN) in the primary liver cancer group were significantly higher than those in the benign liver disease group, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that serum GPC-3, PHCA and GP73

关 键 词：原发性肝癌 磷脂酰肌醇蛋白多糖-3 人肝癌抗原 高尔基体蛋白73 肝纤维化 

分 类 号：R735.7[医药卫生—肿瘤]