肢端恶性黑色素瘤伴肺转移1例  

Acral malignant melanoma with lung metastasis:a case report

作　　者：马文杰 王彤 邹孜瑊 徐宇 胡涂 孙伟 陈勇 Ma Wenjie;Wang Tong;Zou Zijian;Xu Yu;Hu Tu;Sun Wei;Chen Yong(Department of Musculoskeletal Surgery,Fudan University Shanghai Cancer Center,Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属肿瘤医院骨与软组织外科,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中华转移性肿瘤杂志》2024年第6期644-648,共5页Chinese Journal of Metastatic Cancer

摘　　要：肢端恶性黑色素瘤是指发生在四肢末端无毛囊覆盖部位的恶性黑色素瘤,原发于肢端的恶性黑色素瘤患者占中国黑色素瘤病例的40%以上。本例患者左拇指远节恶性黑色素瘤病灶切除术后第6年出现左腋下淋巴结转移,1年后发现右肺转移,经一线帕博利珠单抗免疫治疗,二线维莫非尼靶向治疗无效后,三线特瑞普利单抗联合替莫唑胺治疗的联合方案效果显著。Acral melanoma is a malignant melanoma occurring on hairless regions at the extremities.More than 40%of melanoma cases in China are acral melanomas.In this case,the patient developed left axillary lymph node metastasis six years after excision of a distal left thumb acral melanoma lesion,followed by right lung metastasis one year later.After first-line pembrolizumab immunotherapy and second-line vemurafenib targeted therapy proved ineffective,a combination regimen of third-line toripalimab and temozolomide showed significant efficacy.

关 键 词：恶性黑色素瘤 肺转移 免疫治疗 化学治疗 

分 类 号：R73[医药卫生—肿瘤]