STR突变对亲缘关系鉴定的影响  

The Impact of STR Mutations on Kinship Identification

作　　者：刘京 王正[1] 侯一平[1] 廖林川[1] LIU Jing;WANG Zheng;HOU Yi-ping;LIAO Lin-chuan(West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西基础医学与法医学院,四川成都610041

出　　处：《法医学杂志》2024年第5期484-491,共8页Journal of Forensic Medicine

基　　金：上海市法医学重点实验室暨司法部司法鉴定重点实验室开放课题资助项目(KF202310);法医遗传学公安部重点实验室开放课题资助项目(2023FGKFKT03)。

摘　　要：亲缘关系鉴定是法医遗传学研究的重要领域,广泛应用于遗产纠纷、刑事侦查以及重大灾害案件中受害者的识别等。目前,基于毛细管电泳的STR分析仍然是亲缘关系鉴定的主要方法,但STR突变对亲缘关系鉴定的影响还需探索。本文综述了亲缘关系鉴定的理论基础以及国内外研究现状,并针对STR突变对亲缘关系鉴定的影响这一挑战进行展望,探讨可能的解决途径,以期获得STR突变对亲缘关系鉴定影响的规律性认识,提升亲缘关系分析的准确性。Kinship identification is an important field of forensic genetics research,which can be widely applied in inheritance disputes,criminal investigations,and the identification of victims in major disaster cases.At present,capillary electrophoresis-based STR analysis is still the main method for kinship identification,but the impact of STR mutations on kinship identification needs further exploration.This paper reviews the theoretical basis and research status at home and abroad of kinship identification.The challenge of STR mutation impact on kinship identification is prospected,and possible solutions are discussed in order to obtain a regular understanding of the impact of STR mutation on kinship identification and improve the accuracy of kinship analysis.

关 键 词：法医遗传学 亲缘关系鉴定 STR突变 遗传标记 分析方法 综述 

分 类 号：R89[医药卫生—法医学] DF795.2[医药卫生—临床医学] D919.2[政治法律—诉讼法学]