血管升压素V2受体再认识  

Revisiting the vasopressin V2 receptor

作　　者：李蒙 王蔚东[2] 李春凌[1] LI Meng;WANG Wei-Dong;LI Chun-Ling(Department of Physiology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;Department of Pathophysiology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学中山医学院生理教研室,广州510080 [2]中山大学中山医学院病理生理教研室,广州510080

出　　处：《生理学报》2024年第6期893-907,共15页Acta Physiologica Sinica

基　　金：supported by the National Natural Science Foundation of China(No.82170693,82270744,82370679,81970623);the Natural Science Foundation of Guangdong Province,China(No.2022A1515010787,2021A1515011482).

摘　　要：精氨酸血管升压素(arginine vasopressin,AVP)参与机体水的重吸收、心血管稳态、激素分泌和社会行为等诸多生理过程的调控。AVP有三种受体亚型:V1a、V1b和V2。血管升压素V2受体(vasopressin V2 receptor,V2R)最初发现于肾脏集合管主细胞,主要参与调节肾脏对水的重吸收,但近年来,日益成熟的影像学及生物信息学等技术使研究者对V2R的微观结构、蛋白质结合与具体分布有了更多的了解,并通过异位过表达、激动或拮抗等方式发现V2R在很多疾病中的靶点作用。本文拟就近年来有关V2R的生理功能、病理生理机制与相关药物的研究现状进行简要综述。Arginine vasopressin(AVP)plays a crucial role in various physiological processes including water reabsorption,cardiovascular homeostasis,hormone secretion,and social behavior.AVP acts through three distinct receptor subtypes,i.e.,V1a,V1b,and V2.Among them,the vasopressin V2 receptor(V2R)was initially discovered in the principal cells of renal collecting ducts,where it is primarily involved in regulating water reabsorption.However,in recent years,with the advancement of imaging and bioinformatics techniques,there has been a deeper understanding of the microstructure,protein binding capacity,and specific tissue distribution of V2R.Additionally,the pathogenic roles and target effects of V2R in various diseases have been uncovered through ectopic overexpression,activation,or antagonism.This paper aims to provide a brief overview of current research status on the physiological functions,pathophysiological mechanisms,and drug development related to V2R in recent years.

关 键 词：精氨酸血管升压素 血管升压素V2受体 抗利尿激素抵抗 环磷酸腺苷 

分 类 号：R73[医药卫生—肿瘤]