Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma  

作　　者：Ruheng Hua Pengfei Yu Wanting Zheng Nuwa Wu Wangjianfei Yu Qingyu Kong Jun He Lei Qin 

机构地区：[1]Department of General Surgery,the First Affiliated Hospital of Soochow University,Suzhou 215006,China [2]Department of Gastrointestinal Surgery,Affiliated Hospital of Nantong University,Nantong 226001,China [3]Affiliated Huishan Hospital of Xinglin College,Nantong University,Wuxi Huishan District People’s Hospital,Wuxi 214100,China [4]Research Institute of General Surgery,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210095,China

出　　处：《Acta Biochimica et Biophysica Sinica》2024年第12期1761-1773,共13页生物化学与生物物理学报(英文版)

基　　金：supported by the grants from the National Natural Science Foundation of China for Young Scientists(No.81802385);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX23_1669).

摘　　要：Tim-1(T-cell immunoglobulin and mucin domain 1),also known as Kim-1(kidney injury molecule 1)or hepatitis A virus cellular receptor 1(HAVCR1),is a transmembrane protein expressed on various immune and epithelial cells.It plays a role in modulating inflammatory and immune responses.In this study,we find that Tim-1 is overexpressed in hepatocellular carcinoma(HCC)samples and that its expression is significantly correlated with postoperative survival.Bulk RNA sequencing reveals a general upregulation of extracellular matrix-related genes in HCC tissues with Tim-1 overexpression.The results of the cell and in vivo experiments reveal that Tim-1 in HCC not only affects biological processes such as the proliferation,migration,and invasion of HCC cells but also broadly promotes extracellular matrix processes by influencing cytokine secretion.Further studies demonstrate that Tim-1 mediates the activation of hepatic stellate cells and upregulates Th1 and Th2 cytokines,thereby promoting HCC progression.Thus,Tim-1 may represent a novel target for future interventions in HCC and liver fibrosis.

关 键 词：TIM-1 extracellular matrix hepatocellular carcinoma NF-κB liver fibrosis 

分 类 号：R735.7[医药卫生—肿瘤]