基于Box-Behnken响应面法结合BP神经网络优化决明子脐贴的处方  

Optimization of the Prescription of Cassiae Semen Umbilical Patch Based on Box-Behnken Response Surface Method Combined with BP Neural Network

作　　者：黄莉 程索婷 邹纯才 鄢海燕 HUANG Li;CHENG Suoting;ZOU Chuncai;YAN Haiyan(School of Pharmacy,Wannan Medical College,Wuhu 241002,China)

机构地区：[1]皖南医学院药学院,安徽芜湖241002

出　　处：《中国现代应用药学》2025年第1期79-88,共10页Chinese Journal of Modern Applied Pharmacy

基　　金：安徽高校省级自然科学研究重大项目(KJ2015ZD41、KJ2016SD60);2021年皖南医学院大学生科研资助项目(WK2021XS42);皖南医学院药学院科技发展基金(21020010002);2019年度安徽省省级质量工程项目药剂学(2019kfkc084)。

摘　　要：目的优化决明子脐贴的处方。方法以外观、橙黄决明素与大黄酚峰面积之和、有效成分总峰面积为评价指标,采用单因素试验、Box-Behnken响应面结合BP神经网络优化脐贴处方中的PEG6000∶PEG4000、载药量、薄荷醇用量,制备决明子脐贴。结果将Box-Behnken响应面法试验结果与BP神经网络预测结果相互检验,验证结果综合评价指标平均值分别为0.976、1.040。与Box-Behnken响应面验证试验比较,BP神经网络综合评价指标更高且差异有统计学意义(P<0.01)。择优确定了BP神经网络预测结果为脐贴最优处方,即PEG6000∶PEG4000为3∶2(g∶g)、载药量为14.8%、薄荷醇用量为4.2%。结论该处方制得的决明子脐贴外观光滑平整、无气泡,具有良好的皮肤渗透性。OBJECTIVE To optimize the prescription of Cassiae Semen umbilical patch.METHODS Taking appearance,the sum of peak areas of aurantio-obtusin and chrysophanol,and the total peak area of active ingredients as evaluation indexes.A single factor experiments,Box-Behnken response surface methodology combined with BP neural network were used to optimize the PEG6000∶PEG4000,drug loading,and menthol dosage in umbilical patch formulations,and prepare Cassiae Semen umbilical patch.RESULTS The test results of Box-Behnken response surface method and the prediction results of BP neural network were tested each other,and the average comprehensive evaluation index values of the validation results were 0.976 and 1.040,respectively.Compared with the Box-Behnken response surface validation test,the comprehensive evaluation index of BP neural network was higher and the different was statistically significant(P<0.01).The prediction result of BP neural network were selected as the optimal prescription for umbilical patch,that was,PEG6000∶PEG4000 ratio of 3∶2(g∶g),drug loading of 14.8%,and menthol dosage of 4.2%.CONCLUSION Cassiae Semen umbilical patch prepared with this prescription has a smooth and flat appearance,no bubbles,and good skin permeability.

关 键 词：决明子脐贴 单因素试验 体外经皮渗透试验 Box-Behnken响应面 BP神经网络 

分 类 号：R283.6[医药卫生—中药学]