Neurostructural changes in schizophrenia and treatment-resistance:a narrative review  

作　　者：Tanya Paul Jia Whei See Vetrivel Vijayakumar Temiloluwa Njideaka-Kevin Hanyou Loh Vivian Jia Qi Lee Bekir Nihat Dogrul 

机构地区：[1]Department of Medicine,Avalon University School of Medicine,World Trade Center,Willemstad,Curaçao [2]General Medicine,Universitas Sriwijaya,Palembang City 30114,Indonesia [3]Department of Psychiatry,United Health Services Hospitals,Johnson City,New York 13790,USA [4]Department of Psychiatry,University of Rochester Medical Center,Rochester,New York 14642,USA

出　　处：《Psychoradiology》2024年第1期92-103,共12页精神影像学(英文)

摘　　要：Schizophrenia is a complex disorder characterized by multiple neurochemical abnormalities and structural changes in the brain.These abnormalities may begin before recognizable clinical symptoms appear and continue as a dynamic process throughout the illness.Recent advances in imaging techniques have significantly enriched our comprehension of these structural alterations,particularly focusing on gray and white matter irregularities and prefrontal,temporal,and cingulate cortex alterations.Some of the changes suggest treatment resistance to antipsychotic medications,while treatment nonadherence and relapses may further exacerbate structural abnormalities.This narrative review aims to discuss the literature about alterations and deficits within the brain,which could improve the understanding of schizophrenia and how to interpret neurostructural changes.

关 键 词：SCHIZOPHRENIA magnetic resonance imaging PET SPECT gray matter treatment-resistant schizophrenia 

分 类 号：R73[医药卫生—肿瘤]