Effectiveness and possible brain mechanisms of cervical invasive vagus nerve stimulation(iVNS)intervention for avoidant/restrictive food intake disorder:a case report  

作　　者：Suping Cai Yihan Wang Bofeng Zhao Xiaoliang Li Huan He Kai Yuan Qingchuan Zhao Qinxian Huang Bin Yang Gang Ji 

机构地区：[1]School of Life Sciences and Technology,Xidian University,Xi’an,Shaanxi 710071,PR China [2]Xi’an International Medical Center Hospital,Northwest University,Xi’an,Shaanxi 710100,PR China [3]National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases,Xijing Hospital,Air Force Medical University,Xi’an,Shaanxi 710032,PR China

出　　处：《Psychoradiology》2024年第1期236-242,共7页精神影像学(英文)

基　　金：supported by Shaanxi innovation ability support plan,Science and technology innovation team[2021TD-43];the Xidian university specially funded project for interdisciplinary exploration[grant No.TZJH2024017];the Fundamental Research Funds for the Central Universities[grant no.ZYTS24151];the Key Research and Development Program of Shaanxi Province[Grant No.2023-YBSF-204].

摘　　要：Background We reported a case of cervical invasive vagus nerve stimulation(iVNS)treatment for avoidant/restrictive food intake disorder(ARFID)in a patient with severe anxiety and depression.This patient was even given a critical illness notice during his hospitalization and all treatment efforts were failed.Objective We aimed to verfiy the effectiveness of iVNS in a patient with ARFID.Methods We first attempted to perform cervical iVNS in this case and then observed the changes in clinical scores.We also analyzed the alterations in brain magnetic resonance imaging characteristics before and after iVNS using multi-modal neuroimagings.Results After 18 days of iVNS(from 1 to 19 July 2023),the patient's clinical symptoms improved significantly and he rapidly gained 5 kg in weight.The brain functional characteristics of this patient tended toward those of the normal group.Functional connectivities of the medial of orbitalis prefrontal cortex returned to the normal range after iVNS.Conclusion This is a precedent for performing cervical iVNS in an ARFID patient.Brain neural activity can be modulated through iVNS.The observed improvements in clinical scores and positive changes in brain function validated the effectiveness of iVNS.This case study provides evidence that this intervention technique could be used to reduce the burden on more similar ARFID patients.

关 键 词：avoidant/restrictive food intake disorder invasive vagus nerve stimulation brain magnetic resonance imaging ANXIETY depression abdominal distension 

分 类 号：R73[医药卫生—肿瘤]