血清FABP4、GRP78及FOXO1与急性脑梗死患者预后的相关性  

Correlation of serum FABP4,GRP78 and FOXO1 with prognosis in patients with acute cerebral infarction

作　　者：任晓飞 刘娜 耿颖 甄运钰 芮淑红 REN Xiaofei;LIU Na;GENG Ying;ZHEN Yunyu;RUI Shuhong(Department of Emergency,the Second Affiliated Hospital of Hebei University of Chinese Medicine,Baoding,Hebei 073000,China;The First Department of Neurology,the Second Affiliated Hospital of Hebei University of Chinese Medicine,Baoding,Hebei 073000,China;Department of Medicine,the Second Affiliated Hospital of Hebei University of Chinese Medicine,Baoding,Hebei 073000,China;Department of Critical Care Medicine,the Second Affiliated Hospital of Hebei University of Chinese Medicine,Baoding,Hebei 073000,China)

机构地区：[1]河北中医药大学第二附属医院急诊科,河北保定073000 [2]河北中医药大学第二附属医院神经内一科,河北保定073000 [3]河北中医药大学第二附属医院医务科,河北保定073000 [4]河北中医药大学第二附属医院重症医学科,河北保定073000

出　　处：《检验医学与临床》2025年第3期304-308,共5页Laboratory Medicine and Clinic

基　　金：河北省医学科学研究课题(20190779)。

摘　　要：目的探讨脂肪酸结合蛋白4(FABP4)、葡萄糖调节蛋白78(GRP78)、叉头框转录因子O亚族1(FOXO1)与急性脑梗死(ACI)患者预后的相关性。方法选取2021年6月至2023年1月该院收治的148例ACI患者(ACI组)作为研究对象,另选取148例同期于该院进行体检的健康体检者作为对照组。根据ACI患者出院后3个月的预后情况将其分为预后良好组和预后不良组;比较各组血清FABP4、GRP78、FOXO1水平;采用多因素Logistic回归分析ACI患者预后不良的影响因素。绘制受试者工作特征(ROC)曲线分析血清FABP4、GRP78、FOXO1单独及联合检测对ACI患者预后不良的预测价值。结果ACI组血清FABP4、GRP78水平均高于对照组,FOXO1水平低于对照组,差异均有统计学意义(P<0.05)。预后良好组纳入92例,预后不良组纳入56例。预后不良组年龄、梗死灶面积均大于预后良好组,FABP4、GRP78水平均高于预后良好组,FOXO1水平低于预后良好组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,FABP4、GRP78、FOXO1、年龄、梗死灶面积是ACI患者预后不良的影响因素(P<0.05)。ROC曲线分析结果显示,血清FABP4、GRP78、FOXO1单独及联合预测ACI患者预后不良的曲线下面积(AUC)分别为0.795、0.819、0.784、0.927;血清FABP4、GRP78、FOXO13项联合预测ACI患者预后不良的AUC优于各自单独预测的AUC(Z_(联合检测-FABP4)=3.909,Z_(联合检测-GRP78)=3.171,Z_(联合检测-FOXO1)=4.494,P<0.05)。结论ACI患者血清FABP4、GRP78水平均升高,FOXO1水平降低,3项联合检测对ACI患者预后有较高的预测价值。Objective To investigate the correlation of fatty acid binding protein 4(FABP4),glucose regulated protein 78(GRP78)and forkhead box transcription factor O subfamily 1(FOXO1)with the prognosis of patients with acute cerebral infarction(ACI).Methods A total of 148 ACI patients(ACI group)admitted to the hospital from June 2021 to January 2023 were selected as the research objects,and 148 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.According to the prognosis of ACI patients at 3 months after discharge,they were divided into good prognosis group and poor prognosis group.The serum levels of FABP4,GRP78 and FOXO1 in each group were compared.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in ACI patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum FABP4,GRP78,FOXO1 alone and combined detection for poor prognosis in ACI patients.Results The serum levels of FABP4 and GRP78 in the ACI group were higher than those in the control group,and the level of FOXO1 was lower than that in the control group,and the differences were statistically significant(P<0.05).There were 92 patients in the good prognosis group and 56 patients in the poor prognosis group.The age and infarct size of ACI patients in the poor prognosis group were larger than those in the good prognosis group,the levels of FABP4 and GRP78 were higher than those in the good prognosis group,and the level of FOXO1 was lower than that in the good prognosis group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that FABP4,GRP78,FOXO1,age and infarct size were the influencing factors of poor prognosis in ACI patients(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum FABP4,GRP78,FOXO1 alone and in combination for predicting the poor prognosis of ACI patients was 0.795,0.819,0.784,0.927 respectively.The AUC of th

关 键 词：脂肪酸结合蛋白4 葡萄糖调节蛋白78 叉头框转录因子O亚族1 急性脑梗死 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]