Body-worn and self-powered flexible optoelectronic device for metronomic photodynamic therapy  

作　　者：Jianhong Zhang Xinhui Mao Qingyan Jia Renhao Nie Yangyang Gao Kai Tao Honglong Chang Peng Li Wei Huang 

机构地区：[1]Frontiers Science Center for Flexible Electronics(FSCFE),Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials and Engineering(IBME),Northwestern Polytechnical University,127 West Youyi Road,Xi’an,China [2]Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace,School of Mechanical Engineering,Northwestern Polytechnical University,127 West Youyi Road,Xi’an,China [3]Key laboratory of Flexible Electronics of Zhejiang Province,Ningbo Institute of Northwestern Polytechnical University,218 Qingyi Road,Ningbo,China [4]School of Flexible Electronics(SoFE)and Henan Institute of Flexible Electronics(HIFE),Henan University,379 Mingli Road,Zhengzhou,China

出　　处：《npj Flexible Electronics》2024年第1期278-291,共14页npj-柔性电子(英文)

基　　金：supported by the National Natural Science Foundation of China(52473265,52273302,62288102);Shaanxi Provincial Science Fund for Distinguished Young Scholars(2023-JC-JQ-32);Ningbo Natural Science Foundation(2021J050);Innovation Foundation for Doctorate Dissertation of Northwestern Polytechnical University(CX2021120).

摘　　要：Photodynamic therapy(PDT)as a clinical method relies on appropriate light delivery to activate photosensitizers,usually necessitates the utilization of cumbersome surgical instruments and high irradiation intensity,along with the requirement for hospitalization.To extend the applicability of PDT beyond hospital for better patient mobility,we design a wearable and self-powered metronomic PDT(mPDT)systemfor chronic wound infection treatment.Aflexible alternative current electroluminescent(ACEL)device is constructed through sandwiching an emissive layer between conductive hydrogel electrodes.This ACEL device works as a therapeutic patch by loading photosensitizer(PS)in its bottom hydrogel electrode,thus aviods the intravenous administration to patients.Under the triboelectric nanogenerator generated AC pulse,the electroluminescence produced from emissive layer can be absorbed by the PS-loaded electrode to generate reactive oxygen species for mPDT.Benefited from its arbitrary tailorability,this device can be customized into on-demand shapes and sizes.Using diabetic infected wound as a model condition,this ACEL mPDT device effectively eliminates drug-resistant bacteria and accelerates wound healing.Thus,the body-worn optoelectronic device successfully avoids the utilization of extracorporeal physical light and power sources,providing a promising strategy for convenient,user-friendly,and prolonged treatment of superficial diseases.

关 键 词：WOUND OPTOELECTRONIC eliminate 

分 类 号：R73[医药卫生—肿瘤]